ArticleJAMA dermatology2016
Antibiotic Exposure, Infection, and the Development of Pediatric Psoriasis: A Nested Case-Control Study.
Article in JAMA dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Antistreptococcal interventions for guttate and chronic plaque psoriasis.The Cochrane database of systematic reviews · 2019Pooled it
- Early Childhood Antibiotics and Chronic Pediatric Conditions: A Retrospective Cohort Study.The Journal of infectious diseases · 2025Article
- Microbiota and IL-33/31 Axis Linkage: Implications and Therapeutic Perspectives in Atopic Dermatitis and Psoriasis.Biomolecules · 2023Review
- Compositional Alteration of Gut Microbiota in Psoriasis Treated with IL-23 and IL-17 Inhibitors.International journal of molecular sciences · 2023Article
- Association of Metabolic Comorbidities with Pediatric Psoriasis: A Systematic Review and Meta-Analysis.Annals of dermatology · 2021Article
- Real-World Evidence to Assess Medication Safety or Effectiveness in Children: Systematic Review.Drugs - real world outcomes · 2020Review
- Crucial Role of Microbiota in Experimental Psoriasis Revealed by a Gnotobiotic Mouse Model.Frontiers in microbiology · 2019Article
- Skin Microbiome: An Actor in the Pathogenesis of Psoriasis.Chinese medical journal · 2018Article
- The Role of the Skin and Gut Microbiome in Psoriatic Disease.Current dermatology reports · 2017Article
- Clinical Evidence for the Microbiome in Inflammatory Diseases.Frontiers in immunology · 2017Review
- Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthritis Following Lyme Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- The microbiota in pediatric rheumatic disease: epiphenomenon or therapeutic target?Current opinion in rheumatology · 2016Review
- Antibiotics, obesity and the link to microbes - what are we doing to our children?BMC medicine · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
importanceAntibiotics disrupt human microbiota and have been associated with several pediatric autoimmune diseases. Psoriasis activity has been linked to group A streptococcal and viral infections.
objectiveTo determine whether antibiotic exposure and infections are independently associated with incident psoriasis in children. DESIGN, SETTING, AND
participantsThis nested case-control study used data from the Health Improvement Network database, a population-representative electronic health records database from the United Kingdom, from June 27, 1994, through January 15, 2013. Data were analyzed from September 17, 2014, through August 12, 2015. Children aged 1 to 15 years with newly diagnosed psoriasis (n = 845) were compared with age- and sex-matched controls (n = 8450) randomly chosen at the time of psoriasis diagnosis from general practices with at least one case, excluding children with immunodeficiency, inflammatory bowel disease, and juvenile arthritis. EXPOSURES: Systemic antibacterial prescriptions and infections of the skin and other sites within 2 years before psoriasis diagnosis. MAIN OUTCOMES AND MEASURES: Incident psoriasis as determined by validated diagnostic codes. The association of antibiotic exposure and infections with incident psoriasis was determined by conditional logistic regression, adjusting for confounders.
resultsAfter adjusting for matching, country, socioeconomic deprivation, outpatient visits, and infections within the past 2 years, antibiotic exposure in the last 2 years was weakly associated with incident psoriasis (adjusted odds ratio [aOR], 1.2; 95% CI, 1.0-1.5). The associations for infections of skin (aOR, 1.5; 95% CI, 1.2-1.7) and other sites (aOR, 1.3; 95% CI, 1.1-1.6) were similar. Untreated nonskin infections (aOR, 1.5; 95% CI, 1.3-1.8) but not antibiotic-treated nonskin infections (aOR, 1.1; 95% CI, 0.9-1.4) were associated with psoriasis. Results were similar when using a lifetime exposure window. Different classes of antibiotics and age of first antibiotic exposure were also not associated with psoriasis. The findings did not substantively change when excluding periods of varying length before diagnosis. CONCLUSIONS AND RELEVANCE: Infections are associated with the development of pediatric psoriasis, but antibiotics do not appear to contribute substantially to that risk.
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Registered trials
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