ArticleWorld journal of surgery2016
Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes.
Article in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Current opinions on CEA in the diagnosis and prognosis of colorectal cancer.Translational oncology · 2026Review
- A predictive nomogram for assessing the likelihood of retrieving 12 lymph nodes after rectal cancer surgery: a single-center study.Frontiers in oncology · 2025Article
- Elevated postoperative carcinoembryonic antigen guides adjuvant chemotherapy for stage II colon cancer: a multicentre cohort retrospective study.Scientific reports · 2024Article
- Article
- High postoperative carcinoembryonic antigen as an indicator of high-risk stage II colon cancer.Oncology letters · 2022Article
- Prognostic Value of EGFR Expression for Patients With Stage III Colorectal Cancer Receiving Fluoropyrimidine Metronomic Maintenance Therapy After Radical Resection and Adjuvant Oxaliplatin-Based Chemotherapy.Oncology research · 2021Article
- Prognostic value of the ratio of carcinoembryonic antigen concentration to maximum tumor diameter in patients with stage II colorectal cancer.Journal of gastrointestinal oncology · 2021Article
- Stage migration resulting from inadequate number of examined lymph nodes impacts prognosis in stage II colon cancer after radical surgery.International journal of colorectal disease · 2021Article
- Evaluation of the prognostic relevance of the recommended minimum number of lymph nodes in colorectal cancer-a propensity score analysis.International journal of colorectal disease · 2021Article
- A nomogram for predicting overall survival in patients with resected non-small cell lung cancer treated with chemotherapy.Translational lung cancer research · 2021Article
- Association of perioperative serum carcinoembryonic antigen level and recurrence in low-risk stage IIA colon cancer.PloS one · 2021Article
- Association Between Serum Carcinoembryonic Antigen Levels at Different Perioperative Time Points and Colorectal Cancer Outcomes.Frontiers in oncology · 2021Article
- Clinical Significance of and Predictive Risk Factors for the Postoperative Elevation of Carcinoembryonic Antigen in Patients With Non-Metastatic Colorectal Cancer.Frontiers in oncology · 2021Article
- Gut butyrate-producing organisms correlate to Placenta Specific 8 protein: Importance to colorectal cancer progression.Journal of advanced research · 2020Article
- Prognostic values of CEA, CA19-9, and CA72-4 in patients with stages I-III colorectal cancer.International journal of clinical and experimental pathology · 2020Article
- Identification of Genomic Alterations of Perineural Invasion in Patients with Stage II Colorectal Cancer.OncoTargets and therapy · 2020Article
- The prognostic value of the postoperative serum CEA levels/preoperative serum CEA levels ratio in colorectal cancer patients with high preoperative serum CEA levels.Cancer management and research · 2019Article
- Association of Preoperative and Postoperative Serum Carcinoembryonic Antigen and Colon Cancer Outcome.JAMA oncology · 2018Article
- The impacts of surgery of the primary cancer and radiotherapy on the survival of patients with metastatic rectal cancer.Oncotarget · 2017Article
- Stromal Expression of Vimentin Predicts the Clinical Outcome of Stage II Colorectal Cancer for High-Risk Patients.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to determine which aspects of tumor histology influence postoperative early relapse and overall survival rates after radical resection of stage II colorectal cancer (CRC).
methodsData were collected for 425 patients with stage II CRC who began treatment at a single institution between January 2006 and October 2013. All the enrolled patients were followed up on until death or until December 2014. Clinically significant factors affecting postoperative early relapse and overall survival rates were analyzed.
resultsUsing a multivariate analysis, tumor invasion depth (P = 0.008), vascular invasion (P = 0.029), postoperative carcinoembryonic antigen (CEA) level (P = 0.001), and retrieval of less than 12 lymph nodes (P = 0.002) were found to be independent predictors for postoperative early relapse. A combination of tumor invasion depth, vascular invasion, postoperative CEA level, and number of lymph nodes retrieved showed that the greater the number of predictors involved, the higher the likelihood of postoperative early relapse and the poorer the overall survival.
conclusionsThis study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters.
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