Evidence map›Paper›PMID 26560139›Full record

SynthesisCurrent hypertension reports2015

Interventions to Improve Medication Adherence in Hypertensive Patients: Systematic Review and Meta-analysis.

Vicki S Conn, Todd M Ruppar, Jo-Ana D Chase, Maithe Enriquez, Pamela S Cooper

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current hypertension reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  8. A systematic overview of systematic reviews evaluating medication adherence interventions.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2020
    Pooled it
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  11. Guideline
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vicki S ConnSchool of Nursing, University of Missouri, S317 Sinclair Building, Columbia, MO, 65211, USA. conn@missouri.edu.
Todd M RupparSchool of Nursing, University of Missouri, S423 Sinclair Building, Columbia, MO, 65211, USA.
Jo-Ana D ChaseSchool of Nursing, University of Missouri, S343 Sinclair Building, Columbia, MO, 65211, USA.
Maithe EnriquezSchool of Nursing, University of Missouri, S327 Sinclair Building, Columbia, MO, 65211, USA.
Pamela S CooperSchool of Nursing, University of Missouri, S318 Sinclair Building, Columbia, MO, 65211, USA.

Funding

Meta-Analysis of Interventions to Improve Medication AdherenceR01NR011990 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI CONN, VICKI S · 2010 to 2013
$1.7M
Peers keep it real: reaching 100% adherence to HIV treatmentK01NR014409 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI ENRIQUEZ, MAITHE · 2013 to 2015
$276k
NINR NIH HHS K01 NR014409NINR NIH HHS R01 NR011990NINR NIH HHS R01NR011990
6 · The paper itself

Abstract

This systematic review applied meta-analytic procedures to synthesize medication adherence interventions that focus on adults with hypertension. Comprehensive searching located trials with medication adherence behavior outcomes. Study sample, design, intervention characteristics, and outcomes were coded. Random-effects models were used in calculating standardized mean difference effect sizes. Moderator analyses were conducted using meta-analytic analogues of ANOVA and regression to explore associations between effect sizes and sample, design, and intervention characteristics. Effect sizes were calculated for 112 eligible treatment-vs.-control group outcome comparisons of 34,272 subjects. The overall standardized mean difference effect size between treatment and control subjects was 0.300. Exploratory moderator analyses revealed interventions were most effective among female, older, and moderate- or high-income participants. The most promising intervention components were those linking adherence behavior with habits, giving adherence feedback to patients, self-monitoring of blood pressure, using pill boxes and other special packaging, and motivational interviewing. The most effective interventions employed multiple components and were delivered over many days. Future research should strive for minimizing risks of bias common in this literature, especially avoiding self-report adherence measures.

Indexed as

Medication AdherenceHumansHypertensionRisk FactorsTreatment OutcomeHypertensionMedication adherenceMeta-analysisPatient compliance

Identifiers

PMID26560139
PMCPMC5662945

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.