ArticleScientific reports2015
Multi-Toxin Resistance Enables Pink Bollworm Survival on Pyramided Bt Cotton.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Fitness costs and biological adaptability of Cry toxin-resistant field strains of Pink bollworm, Pectinophora Gossypiella (Saunders) from India.Scientific reports · 2025Article
- Genome-wide analysis reveals distinct global populations of pink bollworm (Pectinophora gossypiella).Scientific reports · 2023Article
- Review
- Segregation ofGenes · 2022Article
- Functional Diversity of the Lepidopteran ATP-Binding Cassette Transporters.Journal of molecular evolution · 2022Review
- Mutation in the Cadherin Gene Is a Key Factor for Pink Bollworm Resistance to Bt Cotton in China.Toxins · 2022Article
- CRISPR-mediated mutations in the ABC transporter gene ABCA2 confer pink bollworm resistance to Bt toxin Cry2Ab.Scientific reports · 2021Article
- Transgenic cotton and sterile insect releases synergize eradication of pink bollworm a century after it invaded the United States.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cadherin repeat 5 mutation associated with Bt resistance in a field-derived strain of pink bollworm.Scientific reports · 2020Article
- Evidence for population expansion of Cotton pink bollworm Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae) in India.Scientific reports · 2020Article
- Transposon insertion causes cadherin mis-splicing and confers resistance to Bt cotton in pink bollworm from China.Scientific reports · 2019Article
- ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-selected pink bollworm.Scientific reports · 2018Article
- Review
- A new observation on feeding behaviour of pink bollworm and its application in screening3 Biotech · 2018Article
- Pool deconvolution approach for high-throughput gene mining from Bacillus thuringiensis.Applied microbiology and biotechnology · 2018Article
- Surge in insect resistance to transgenic crops and prospects for sustainability.Nature biotechnology · 2017Review
- Resistance toEvolutionary applications · 2017Article
- Comparisons of Transcriptional Profiles of Gut Genes between Cry1Ab-Resistant and Susceptible Strains of Ostrinia nubilalis Revealed Genes Possibly Related to the Adaptation of Resistant Larvae to Transgenic Cry1Ab Corn.International journal of molecular sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transgenic crops producing Bacillus thuringiensis (Bt) proteins kill key insect pests, providing economic and environmental benefits. However, the evolution of pest resistance threatens the continued success of such Bt crops. To delay or counter resistance, transgenic plant "pyramids" producing two or more Bt proteins that kill the same pest have been adopted extensively. Field populations of the pink bollworm (Pectinophora gossypiella) in the United States have remained susceptible to Bt toxins Cry1Ac and Cry2Ab, but field-evolved practical resistance to Bt cotton producing Cry1Ac has occurred widely in India. Here we used two rounds of laboratory selection to achieve 18,000- to 150,000-fold resistance to Cry2Ab in pink bollworm. Inheritance of resistance to Cry2Ab was recessive, autosomal, conferred primarily by one locus, and independent of Cry1Ac resistance. We created a strain with high resistance to both toxins by crossing the Cry2Ab-resistant strain with a Cry1Ac-resistant strain, followed by one selection with Cry2Ab. This multi-toxin resistant strain survived on field-collected Bt cotton bolls producing both toxins. The results here demonstrate the risk of evolution of resistance to pyramided Bt plants, particularly when toxins are deployed sequentially and refuges are scarce, as seen with Bt cotton and pink bollworm in India.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.