Evidence map›Paper›PMID 26559893›Full record

ArticleCerebellum (London, England)2016

Mosaic Expression of Thyroid Hormone Regulatory Genes Defines Cell Type-Specific Dependency in the Developing Chicken Cerebellum.

Joke Delbaere, Stijn L J Van Herck, Nele M A Bourgeois, Pieter Vancamp, Shuo Yang, Richard J T Wingate, Veerle M Darras

Abstract read
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In one paragraph

Article in Cerebellum (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Local Thyroid Hormone Action in Brain Development.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Joke DelbaereLaboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Naamsestraat 61, P.O. Box 2464, B-3000, Leuven, Belgium.
Stijn L J Van HerckLaboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Naamsestraat 61, P.O. Box 2464, B-3000, Leuven, Belgium.
Nele M A BourgeoisLaboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Naamsestraat 61, P.O. Box 2464, B-3000, Leuven, Belgium.
Pieter VancampLaboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Naamsestraat 61, P.O. Box 2464, B-3000, Leuven, Belgium.
Shuo YangMedical Research Council Centre for Developmental Neurobiology, King's College London, London, UK.
Richard J T WingateMedical Research Council Centre for Developmental Neurobiology, King's College London, London, UK.
Veerle M DarrasLaboratory of Comparative Endocrinology, Department of Biology, KU Leuven, Naamsestraat 61, P.O. Box 2464, B-3000, Leuven, Belgium. Veerle.Darras@bio.kuleuven.be.
KU Leuven · BEMedical Research Council · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebellum is a morphologically unique brain structure that requires thyroid hormones (THs) for the correct coordination of key cellular events driving its development. Unravelling the interplay between the multiple factors that can regulate intracellular TH levels is a key step to understanding their role in the regulation of these cellular processes. We therefore investigated the regional/cell-specific expression pattern of TH transporters and deiodinases in the cerebellum using the chicken embryo as a model. In situ hybridisation revealed expression of the TH transporters monocarboxylate transporter 8 (MCT8) and 10 (MCT10), L-type amino acid transporter 1 (LAT1) and organic anion transporting polypeptide 1C1 (OATP1C1) as well as the inactivating type 3 deiodinase (D3) in the fourth ventricle choroid plexus, suggesting a possible contribution of the resulting proteins to TH exchange and subsequent inactivation of excess hormone at the blood-cerebrospinal fluid barrier. Exclusive expression of LAT1 and the activating type 2 deiodinase (D2) mRNA was found at the level of the blood-brain barrier, suggesting a concerted function for LAT1 and D2 in the direct access of active T

Indexed as

AnimalsAvian ProteinsBlood-Brain BarrierCell LineageCerebellumChick EmbryoElectroporationGene Expression Regulation, DevelopmentalImmunohistochemistryIn Situ HybridizationMembrane Transport ProteinsMicroscopy, FluorescenceModels, AnimalNeuronsRNA, MessengerSynapsesAvian ProteinsMembrane Transport ProteinsRNA, MessengerThyroid HormonesBrain developmentCerebellumChickenDeiodinasesThyroid hormoneTransporters

Identifiers

PMID26559893
OpenAlexW2248160366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.