ArticleHypertension research : official journal of the Japanese Society of Hypertension2016
Renal glomerular dysfunction in relation to retinal arteriolar narrowing and high pulse pressure in seniors.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association of Retinal Microangiopathy with Albuminuria in Patient with Chronic Kidney Disease: a Meta-analysis Study.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2023Pooled it
- The Retinal Vasculature and Risk of Age-Related GFR Decline - The Renal Iohexol Clearance Survey.Kidney international reports · 2025Article
- Evaluating the potential of retinal photography in chronic kidney disease detection: a review.PeerJ · 2024Review
- Retinal vascular changes and arterial stiffness during 8-month isolation and confinement: the SIRIUS-21 space analog mission.Frontiers in physiology · 2024Article
- Automated Retinal Vessel Analysis Based on Fundus Photographs as a Predictor for Non-Ophthalmic Diseases-Evolution and Perspectives.Journal of personalized medicine · 2023Review
- Short-term duration of diabetic retinopathy as a predictor for development of diabetic kidney disease.Journal of translational internal medicine · 2023Article
- Retinal Vascular Signs as Screening and Prognostic Factors for Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Current Evidence.Journal of personalized medicine · 2021Review
- Association between early-stage chronic kidney disease and reduced choroidal thickness in essential hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Quantitative analysis of the macula with optical coherence tomography angiography in normal Japanese subjects: The Taiwa Study.Scientific reports · 2019Article
- Diminished circadian blood pressure variability in elderly individuals with nuclear cataracts: cross-sectional analysis in the HEIJO-KYO cohort.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Inactive matrix Gla protein is a novel circulating biomarker predicting retinal arteriolar narrowing in humans.Scientific reports · 2018Article
- Comparison of pulse wave velocity and pulse pressure amplification in association with target organ damage in community-dwelling elderly: The Northern Shanghai Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Prognostic significance of home pulse pressure for progression of diabetic nephropathy: KAMOGAWA-HBP study.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Reproducibility of Retinal Microvascular Traits Decoded by the Singapore I Vessel Assessment Software Across the Human Age Range.American journal of hypertension · 2018Article
- Relationship between subtle urinary albumin excretion and risk of incident hypertension: modification by glomerular filtration rate.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- A high-salt diet enhances leukocyte adhesion in association with kidney injury in young Dahl salt-sensitive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal arteriolar narrowing and high pulse pressure (PP) are associated with macrovascular complications and microvascular renal disease. Few studies addressed whether in seniors (⩾60 years) estimated glomerular filtration rate (eGFR) is independently related to central retinal arteriolar equivalent (CRAE) and PP. In 292 randomly recruited seniors (49.3% women; mean, 68.2 years), we measured PP by standard sphygmomanometry, CRAE (IVAN software), eGFR (Chronic Kidney Disease Epidemiology Collaboration equation) and stage of chronic kidney disease (CKD (Kidney Disease Outcomes Quality Initiative guideline)). Statistical methods included linear and logistic regression. PP, CRAE and eGFR averaged 59.2 mm Hg, 146.3 μm and 79.9 ml min(-1) per 1.73 m(2). Decline in eGFR (-2.27 ml min(-1) per 1.73 m(2) per 15 μm; P=0.011) occurred in parallel with CRAE narrowing. CRAE (effect size per 1-s.d. increment, -1.85 μm; P=0.032) and eGFR (-2.68 ml min(-1) per 1.73 m(2); P=0.003) both declined with higher PP. With PP increasing from 63 to 73 mm Hg (threshold for macrovascular complications), CRAE dropped by -4.70 μm (P⩽0.037). A 70-mm Hg PP threshold corresponded with a 150-μm CRAE cutoff. The risk of CKD (stage ⩾2 vs. 1; n=203 vs. 89) rose with CRAE <150 μm (odds ratio, 2.81; P<0.0001), but not with PP ⩾70 mm Hg (1.47; P=0.20). Additionally, CRAE added to PP increased the area under the curve from 0.58 to 0.64 (P=0.047) for identifying stage ⩾2 CKD. In seniors, CRAE and eGFR decline in parallel with higher PP. CRAE <150 μm identifies early decline in eGFR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.