SynthesisRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo2016
[Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review].
Synthesis in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Effect of dietary glycemic index on insulin resistance in adults without diabetes mellitus: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Global prevalence of insulin resistance in the adult population: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Childhood obesity and insulin resistance is correlated with gut microbiome serum protein: an integrated metagenomic and proteomic analysis.Scientific reports · 2025Trial
- Mango Consumption Is Associated with Increased Insulin Sensitivity in Participants with Overweight/Obesity and Chronic Low-Grade Inflammation.Nutrients · 2025Trial
- Effect of a single bout of morning or afternoon exercise on glucose fluctuation in young healthy men.Physiological reports · 2021Trial
- Postprandial Effects of a Proprietary Milk Protein Hydrolysate Containing Bioactive Peptides in Prediabetic Subjects.Nutrients · 2019Trial
- Associations of systemic inflammatory indices and metabolically healthy vs. unhealthy obesity in children.Italian journal of pediatrics · 2026Article
- Identification of a HOMA-IR cut-off point for cardiometabolic risk and modifiable risk factors in peruvian adolescents.PloS one · 2026Article
- Late Effects Following Hematopoietic Stem Cell Transplantation Among Childhood Transplant Survivors with Fanconi AnemiaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Serum vitamin D and obesity among US adolescents, NHANES 2011-2018.Frontiers in pediatrics · 2024Article
- Sleep duration and timing are prospectively linked with insulin resistance during late adolescence.Obesity (Silver Spring, Md.) · 2023Article
- Triglyceride glucose index, pediatric NAFLD fibrosis index, and triglyceride-to-high-density lipoprotein cholesterol ratio are the most predictive markers of the metabolically unhealthy phenotype in overweight/obese adolescent boys.Frontiers in endocrinology · 2023Article
- Reversibility of pancreatic β-cells dysfunction after vitamin D and calcium supplementation: a pilot study in a population of obese and prepubescent North-African children.The Libyan journal of medicine · 2022Article
- Impact of One-Year Dietary Education on Change in Selected Anthropometric and Biochemical Parameters in Children with Excess Body Weight.International journal of environmental research and public health · 2022Article
- Comparison of different severe obesity definitions in predicting future cardiometabolic risk in a longitudinal cohort of children.BMJ open · 2022Article
- A performance review of novel adiposity indices for assessing insulin resistance in a pediatric Latino population.Frontiers in pediatrics · 2022Article
- Familial dietary intervention in children with excess body weight and its impact on eating habits, anthropometric and biochemical parameters.Frontiers in endocrinology · 2022Article
- Effects of severe obesity and sleeve gastrectomy on cortical thickness in adolescents.Obesity (Silver Spring, Md.) · 2021Article
- The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk.International journal of environmental research and public health · 2021Article
- Prevalence of different states of glucose intolerance in Sri Lankan children and adolescents with obesity and its relation to other comorbidities.Pediatric diabetes · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify cutoff points of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established for adolescents and discuss their applicability for the diagnosis of insulin resistance in Brazilian adolescents. DATA SOURCE: A systematic review was performed in the PubMed, Lilacs and SciELO databases, using the following descriptors: "Adolescents", "insulin resistance" and "ROC curve". Original articles carried out with adolescents published between 2005 and 2015 in Portuguese, English or Spanish languages, which included the statistical analysis using ROC curve to determine the index cutoff (HOMA-IR) were included. DATA SYNTHESIS: A total of 184 articles were identified and after the study phases were applied, seven articles were selected for the review. All selected studies established their cutoffs using a ROC curve, with the lowest observed cutoff of 1.65 for girls and 1.95 for boys and the highest of 3.82 for girls and 5.22 for boys. Of the studies analyzed, one proposed external validity, recommending the use of the HOMA-IR cutoff >2.5 for both genders.
conclusionsThe HOMA-IR index constitutes a reliable method for the detection of insulin resistance in adolescents, as long as it uses cutoffs that are more adequate for the reality of the study population, allowing early diagnosis of insulin resistance and enabling multidisciplinary interventions aiming at health promotion of this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.