Evidence map›Paper›PMID 26559501›Full record

Trial reportThe journal of sexual medicine2015

Testosterone Concentrations and Cardiovascular Autonomic Neuropathy in Men with Type 1 Diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC).

Catherine Kim, Rodica Pop-Busui, Barbara Braffett, Patricia A Cleary, Ionut Bebu, Hunter Wessells, Trevor Orchard, Aruna V Sarma, DCCT/E.D.I.C. Research Group

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of sexual medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Catherine KimDepartments of Medicine, Obstetrics and Gynecology, and Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Rodica Pop-BusuiDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.
Barbara BraffettThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Patricia A ClearyThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Ionut BebuThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Hunter WessellsDepartment of Urology, University of Washington, Seattle, WA, USA.
Trevor OrchardDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Aruna V SarmaDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
DCCT/E.D.I.C. Research Group
George Washington University · USUniversity of Michigan–Ann Arbor · USSeattle Reproductive Medicine · USUniversity of Pittsburgh · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- DiabetesR01DK083927 · NIDDK · UNIVERSITY OF WASHINGTON · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2009 to 2013
$2.7M
ReproEDIC: Risk and Progression of Reproductive Abnormalities in Type 1 DiabetesDP3DK098129 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, CATHERINE, SARMA, ARUNA V · 2013 to 2013
$803k
NIDDK NIH HHS DP3 DK098129NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK083927NIDDK NIH HHS R01DK083927NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

introductionPrevious studies have reported that lower testosterone concentrations are associated with cardiovascular autonomic neuropathy (CAN), a risk factor for cardiovascular events. However, no studies have examined this relationship in men with type 1 diabetes, who are at high risk for CAN.

aimThe aim of this study was to examine the associations between testosterone concentrations and measures of CAN in a large, well-characterized cohort of men with type 1 diabetes.

methodsWe conducted an analysis of men in the Diabetes Control and Complications Trial (DCCT), a randomized trial of intensive glucose control, and its observational follow-up the Epidemiology of Diabetes Intervention and Complications (EDIC) Study. Testosterone was measured by liquid chromatography mass spectrometry in stored samples from EDIC follow-up years 10 and 17. Regression models were used to assess the cross-sectional relationships between testosterone and CAN measures.

main outcome measuresThe main CAN measure from EDIC follow-up year 17 was a standardized composite of R-R variation with paced breathing < 15, or R-R variation 15-20 combined with either a Valsalva ratio ≤ 1.5 or a decrease in diastolic blood pressure > 10 mm Hg upon standing. Continuous R-R variation and Valsalva ratio were secondary outcomes.

resultsLower total and bioavailable testosterone concentrations at follow-up years 10 and 17 were not associated with the presence of CAN at year 17. In analyses using Valsalva ratio as a continuous measure, higher total (P = 0.01) and bioavailable testosterone concentrations (P = 0.005) were associated with a higher (more favorable) Valsalva ratio after adjustment for covariates including age, body mass index, smoking status, hypertension, and glycemia.

conclusionsTestosterone levels are not associated with CAN among men with type 1 diabetes. Although testosterone is associated with a higher Valsalva ratio, a more favorable indicator, the clinical significance of this association is not known.

Indexed as

Autonomic Nervous SystemDiabetes ComplicationsDiabetes Mellitus, Type 1TestosteroneAdultAgedBlood GlucoseBlood PressureBody Mass IndexCardiovascular SystemCross-Sectional StudiesHumansHypertensionMaleMiddle AgedRisk FactorsBlood GlucoseTestosteroneCardiovascular Autonomic NeuropathyCardiovascular Reflex TestsTestosteroneType 1 Diabetes

Identifiers

PMID26559501
PMCPMC4825316
OpenAlexW2126185068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.