ArticleNanotoxicology2016
Toxicity assessment and bioaccumulation in zebrafish embryos exposed to carbon nanotubes suspended in Pluronic® F-108.
Article in Nanotoxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Pharmacokinetics and bio-distribution of differently functionalized Carbon nanotube in Zebrafish, Danio rerio.Discover nano · 2026Article
- Non-antibiotic lipid complex-in-thermogel strikes twice: multimodal photosensitive antibacterial meets immunomodulation-boosted healing for periodontitis treatment.Materials today. Bio · 2026Article
- Generation of Formates Following 20 kHz Sonication of DSPE-mPEG2000 PEGylated Phospholipid Micelles.Pharmaceutics · 2025Article
- Zebrafish: A Promising Real-Time Model System for Nanotechnology-Mediated Neurospecific Drug Delivery.Nanoscale research letters · 2021Review
- Scavenger Receptor A1 Mediates the Uptake of Carboxylated and Pristine Multi-Walled Carbon Nanotubes Coated with Bovine Serum Albumin.Nanomaterials (Basel, Switzerland) · 2021Article
- Selective Uptake of Carboxylated Multi-Walled Carbon Nanotubes by Class A Type 1 Scavenger Receptors and Impaired Phagocytosis in Alveolar Macrophages.Nanomaterials (Basel, Switzerland) · 2020Article
- The Importance of Evaluating the Lot-to-Lot Batch Consistency of Commercial Multi-Walled Carbon Nanotube Products.Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects.International journal of nanomedicine · 2019Article
- Quantitation of cell-associated carbon nanotubes: selective binding and accumulation of carboxylated carbon nanotubes by macrophages.Nanotoxicology · 2018Article
- Zebrafish as a Model to Evaluate Nanoparticle Toxicity.Nanomaterials (Basel, Switzerland) · 2018Review
- Increasing evidence indicates low bioaccumulation of carbon nanotubes.Environmental science. Nano · 2017Article
- Detecting Sonolysis of Polyethylene Glycol Upon Functionalizing Carbon Nanotubes.Methods in molecular biology (Clifton, N.J.) · 2017Article
- The impact of subcellular location on the near infrared-mediated thermal ablation of cells by targeted carbon nanotubes.Nanotechnology · 2016Article
- Counter ions and constituents combination affect DODAX : MO nanocarriers toxicityToxicology research · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Carbon nanotubes (CNTs) are often suspended in Pluronic® surfactants by sonication, which may confound toxicity studies because sonication of surfactants can create degradation products that are toxic to mammalian cells. Here, we present a toxicity assessment of Pluronic® F-108 with and without suspended CNTs using embryonic zebrafish as an in vivo model. Pluronic® sonolytic degradation products were toxic to zebrafish embryos just as they were to mammalian cells. When the toxic Pluronic® fragments were removed, there was little effect of pristine multi-walled CNTs (pMWNTs), carboxylated MWNTs (cMWNTs) or pristine single-walled carbon nanotubes (pSWNTs) on embryo viability and development, even at high concentrations. A gel electrophoretic method coupled with Raman imaging was developed to measure the bioaccumulation of CNTs by zebrafish embryos, and dose-dependent uptake of CNTs was observed. These data indicate that embryos accumulate pMWNTs, cMWNTs and pSWNTs yet there is very little embryo toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.