Observational studyMedicine2015
Association Between Statin Use and Open-angle Glaucoma in Hyperlipidemia Patients: A Taiwanese Population-based Case-control Study.
Observational study in Medicine, 2015. The graph read 2 numbers from its abstract, feeding 2 cells of the map, but none could be read as for or against, so it casts no vote. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
Read, but not usablea number the graph found but could not read as for or against
In further subanalysis, we observed that patients with a high dosage of statin exposure (≥120 DDD/y) had a 1.24-fold increased risk of OAG (OR 1.24, 95% CI 1.03-1.49).
After adjustment for age, sex, hypertension, depression, the CCI level, the frequency of eye care visits, year of hyperlipidemia diagnosis, and the use of nonstatin cholesterol-lowering drugs, patients with statin use were not significantly associated with OAG (OR 1.02, 95% CI 0.90-1.15) compared with patients without statin use.
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Where it lands on the map
Rows are treatments, columns are outcomes. The coloured squares are the cells this paper feeds, coloured by the vote it casts there. Click one to jump to what this paper adds to it.
What it adds to each cell
For every cell the paper feeds: the belief in the claim with and without this paper, and this paper's estimate drawn against every other readable study in the cell. The ringed dot is this paper.
Statins×pharmacokinetics & dosing
No readable resultOpen on the map →What to test next →2 readable studies in this cell: 0 favour the treatment, 2 find no difference, 0 favour the comparator.
This paper's own estimate is on a different scale from the rest of the cell, so it is not drawn here.
Statins×lipids
No readable resultOpen on the map →What to test next →38 readable studies in this cell: 25 favour the treatment, 5 find no difference, 8 favour the comparator.
This paper's own estimate is on a different scale from the rest of the cell, so it is not drawn here.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of different types of statins with the risk of open-angle glaucoma: a systematic review and network meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Statin Use and Primary Open-Angle Glaucoma Severity in Patients of African Ancestry.Research square · 2026Article
- Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders.Neuroprotection (Chichester, England) · 2026Review
- Association Between Statin Use and Glaucoma Risk: A Population-Based Study.Investigative ophthalmology & visual science · 2025Article
- Emerging risks of lipid-lowering therapy and low LDL levels: implications for eye, brain, and new-onset diabetes.Lipids in health and disease · 2025Article
- Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects.Scientific reports · 2025Article
- Association between statin use and open-angle glaucoma: a nested case-control study using the Japanese claims database.Scientific reports · 2023Article
- Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma.Frontiers in ophthalmology · 2023Review
- Statins Inhibit the Gliosis of MIO-M1, a Müller Glial Cell Line Induced by TRPV4 Activation.International journal of molecular sciences · 2022Article
- Statin Use in Relation to Intraocular Pressure, Glaucoma, and Ocular Coherence Tomography Parameters in the UK Biobank.Investigative ophthalmology & visual science · 2022Article
- Associations of statin use with the onset and progression of open-angle glaucoma: A systematic review and meta-analysis.EClinicalMedicine · 2022Article
- Types of Glaucoma and Associated Comorbidities Among Patients at King Abdulaziz Medical City, Jeddah.Cureus · 2021Article
- Risk factors leading to trabeculectomy surgery of glaucoma patient using Japanese nationwide administrative claims data: a retrospective non-interventional cohort study.BMC ophthalmology · 2021Article
- Article
- A review of systemic medications that may modulate the risk of glaucoma.Eye (London, England) · 2020Review
- The Role of Statins and Cholesterol in the Primary Prevention of Primary Open-Angle Glaucoma.JAMA ophthalmology · 2019Article
- Association of Statin Use and High Serum Cholesterol Levels With Risk of Primary Open-Angle Glaucoma.JAMA ophthalmology · 2019Article
- Use of Statins and Risk of Reducing Glaucoma: Is There a Link?Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- Ocular and Systemic Factors Associated with Glaucoma.Journal of current glaucoma practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The marked sentences are the ones the graph read a number from.
The aim of the study was to investigate the association between statin use and open-angle glaucoma (OAG) risk in hyperlipidemia patients.We used the research database of the Taiwan National Health Insurance program to conduct a population-based case-control study. A total of 1276 patients with newly diagnosed OAG were identified from 2004 to 2011. Controls comprised of 12,760 patients without glaucoma and were frequency-matched for age, sex, history of diabetes mellitus, and year of hyperlipidemia diagnosis at a 1:10 ratio. Accumulated defined daily doses (DDDs) of statins prescribed during follow-up were calculated. Average statin use was calculated as the sum of DDDs divided by the duration from the initial statin prescription date to the index date (per year), and was subdivided into 3 levels: <30, 30 to 119, and ≥120 DDDs. Comorbidity, including hypertension, depression, and the Charlson comorbidity index, the frequency of eye care visits, and the use of nonstatin cholesterol-lowering drugs, were all considered as confounding factors.For the group with statin use, the adjusted odds ratio of OAG was 1.02 (95% confidence interval 0.90-1.15) when compared with the group without statin use. Subanalysis showed that a high dosage of statin use (≥120 DDD/y) resulted in a1.24-fold increased risk of OAG (odds ratio 1.24, 95% confidence interval 1.03-1.49). The incidence of OAG was increased with the increase of the dosage of statin use (P for trend = 0.0458).Clinicians should be cautious of hyperlipidemia patients with a high dosage of statin use because it might be associated with an increased risk of OAG. Ophthalmologist consultation is necessary for this high-risk group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.