ArticlePediatric nephrology (Berlin, Germany)2016
Acute kidney injury after heart transplant in young children: risk factors and outcomes.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 39 citations in OpenAlex.
- Perioperative anesthetic management in pediatric heart transplantation: a single-center descriptive study involving 27 patients.Frontiers in pediatrics · 2026Article
- Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant.Pediatric transplantation · 2024Article
- Intraoperative and Postoperative Hemodynamic Predictors of Acute Kidney Injury in Pediatric Heart Transplant Recipients.Journal of pediatric intensive care · 2024Article
- Clinical impact of severe acute kidney injury on post-operative and brain injury outcomes in preterm infants following surgical necrotizing enterocolitis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Risk factors and outcomes associated with acute kidney injury following extracardiac total cavopulmonary connection: a retrospective observational study.Translational pediatrics · 2022Article
- Kidney disease in children with heart or liver transplant.Pediatric nephrology (Berlin, Germany) · 2021Review
- Using kinetic eGFR to identify acute kidney injury risk in children undergoing cardiac transplantation.Pediatric research · 2021Article
- Acute kidney injury in hospitalized children: consequences and outcomes.Pediatric nephrology (Berlin, Germany) · 2020Review
- Incidence and Risk Factors of Acute Kidney Injury after Kasai Operation for Biliary Atresia: A Retrospective Study.International journal of medical sciences · 2020Article
- Acute Kidney Injury and Fluid Overload in Pediatric Cardiac Surgery.Current treatment options in pediatrics · 2019Article
- Nephrotoxin exposure and acute kidney injury in critically ill children undergoing congenital cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2018Observational
- Association of Whole Blood Tacrolimus Concentrations with Kidney Injury in Heart Transplantation Patients.European journal of drug metabolism and pharmacokinetics · 2018Observational
- Recovery of renal function in a heart transplantation recipient with over 300 days of iatrogenic anuria: A case report.Medicine · 2018Article
- Epidemiology and outcomes of community-acquired and hospital-acquired acute kidney injury in children and adolescents.Pediatric research · 2018Article
- Assessing acute kidney injury after pediatric heart transplant.Pediatric nephrology (Berlin, Germany) · 2016Article
- Response to comments by Yang and Xue on: "Acute kidney injury after heart transplant in young children: risk factors and outcomes".Pediatric nephrology (Berlin, Germany) · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCritical illness following heart transplantation can include acute kidney injury (AKI). Study objectives were to define the epidemiology of, risk factors for, or impact on outcomes of AKI after pediatric heart transplant.
methodsUsing data from a prospective study of 66 young children, we evaluated: (1) post-operative AKI rate (by pediatric modified RIFLE criteria); (2) pre, intra, and early post-operative AKI risk factors using stepwise logistic regression (3) effect of AKI on short-term outcomes (ventilation and length of pediatric intensive care unit (PICU) stay) using stepwise multiple regression.
resultsAKI occurred in 73 % of children. Pre-transplant ventilation and higher baseline estimated creatinine clearance (eCCl) were independent risk factors for AKI. Pre-operative inotrope use was associated with reduced risk of AKI. Tacrolimus level emerged as important in multivariable risk prediction. Children with AKI had a longer duration of ventilation and length of pediatric intensive care unit (PICU) stay, with AKI being an independent predictor.
conclusionsAKI was common after heart transplant and associated with more complicated early post-transplant course. Lower baseline eCCl was associated with lower incidence of AKI; this merits further investigation. The association of pre-operative inotropes with less AKI may reflect a pathophysiological mechanism or be a surrogate for clinical factors and management prior to transplant. Avoiding high tacrolimus levels may be a modifiable risk factor for AKI.
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