Evidence map›Paper›PMID 26559061›Full record

ArticlePloS one2015

Morphological Analysis of Reticuloendothelial System in Capuchin Monkeys (Sapajus spp.) after Meso-2,3-Dimercaptosuccinic Acid (DMSA) Coated Magnetic Nanoparticles Administration.

Shélida Vasconcelos Braz, Victoria Monge-Fuentes, Jaqueline Rodrigues da Silva, Carlos Tomaz, Maria Clotilde Tavares, Monica Pereira Garcia, Sônia Nair Báo, Silene Paulino Lozzi, Ricardo Bentes de Azevedo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shélida Vasconcelos BrazDepartment of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, 70910-900 Brasília-DF, Brazil.
Victoria Monge-FuentesLaboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, 70910-900 Brasília-DF, Brazil.
Jaqueline Rodrigues da SilvaLaboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, 70910-900 Brasília-DF, Brazil.
Carlos TomazPrimate Center and Laboratory of Neurosciences and Behavior, Department of Physiological Sciences, Institute of Biology, University of Brasília, 70910-900 Brasília, DF, Brazil.
Maria Clotilde TavaresPrimate Center and Laboratory of Neurosciences and Behavior, Department of Physiological Sciences, Institute of Biology, University of Brasília, 70910-900 Brasília, DF, Brazil.
Monica Pereira GarciaLaboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, 70910-900 Brasília-DF, Brazil.
Sônia Nair BáoLaboratory of Electron Microscopy, Department of Cell Biology, University of Brasília, 70919-970 -Brasília, DF, Brazil.
Silene Paulino LozziDepartment of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, 70910-900 Brasília-DF, Brazil.
Ricardo Bentes de AzevedoLaboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, 70910-900 Brasília-DF, Brazil.
Universidade de Brasília · BRCentro Universitário do Maranhão · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic nanoparticles can be used for numerous in vitro and in vivo applications. However, since uptake by the reticuloendothelial system represents an obstacle for the achievement of nanoparticle diagnostic and therapeutic goals, the aim of the present study was to evaluate the uptake of dimercaptosuccinic acid coated magnetic nanoparticles by reticuloendothelial system phagocytic cells present in lymph nodes, spleen, and liver tissue and how the presence of these particles could have an impact on the morphology of these organs in capuchin monkeys (Sapajus spp.). Animals were intravenously injected with dimercaptosuccinic acid coated magnetic nanoparticles and euthanized 12 hours and 90 days post-injection. Organs were processed by transmission electron microscopy and histological techniques. Samples of spleen and lymph nodes showed no morphological changes. Nevertheless, liver samples collected 90 days post-administration showed slight morphological alteration in space of Disse. Moreover, morphometrical analysis of hepatic mitochondria was performed, suggesting a clear positive correlation between mitochondrial area and dimercaptosuccinic acid coated magnetic nanoparticles administration time. The present results are directly relevant to current safety considerations in clinical diagnostic and therapeutic uses of magnetic nanoparticles.

Indexed as

MagneticsNanoparticlesAnimalsCebusLiverLymph NodesMicroscopy, Electron, TransmissionMitochondria, LiverMononuclear Phagocyte SystemSpleenSuccimerSuccimer

Identifiers

PMID26559061
PMCPMC4641670
OpenAlexW2173559465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.