Evidence map›Paper›PMID 26558766›Full record

ArticleEuropean journal of nutrition2017

Plasma vitamin D biomarkers and leukocyte telomere length in men.

Bettina Julin, Irene M Shui, Jennifer Prescott, Edward L Giovannucci, Immaculata De Vivo

Abstract read
In one paragraph

Article in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Bettina JulinChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Irene M ShuiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jennifer PrescottChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Edward L GiovannucciChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Immaculata De VivoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. nhidv@channing.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USFred Hutch Cancer Center · USKarolinska Institutet · SE

Funding

Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Molecular Pathoepidemiology of Endometrial Cancer RiskR01CA082838 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI DE VIVO, IMMACULATA · 1999 to 2015
$4.3M
Energy Balance-Related Hormones & Prostate Cancer Incidence & ProgressionR01CA133891 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI GIOVANNUCCI, EDWARD · 2008 to 2012
$3.3M
NCI NIH HHS R01 CA082838NCI NIH HHS R01 CA133891NCI NIH HHS UM1 CA167552
6 · The paper itself

Abstract

purposeVitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In women, higher plasma 25-hydroxyvitamin D (25(OH)D) has been shown to be associated with longer telomere length, but the relationship has not been assessed in men.

methodsWe conducted a cross-sectional analysis of 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)

resultsAge (P-trend < 0.0001), pack-years of smoking (P-trend = 0.04) and body mass index (P-trend = 0.05) were inversely associated with LTL. Neither 25(OH)D nor 1,25(OH)

conclusionsIn this cross-sectional study of men, 25(OH)D and 1,25(OH)

Indexed as

AgedAge FactorsBiomarkersBody Mass IndexCross-Sectional StudiesGenotypeHumansLeukocytesMaleMiddle AgedPolymerase Chain ReactionPolymorphism, Single NucleotideRetinoid X Receptor alphaSmokingTelomereTelomere Homeostasis1,25-dihydroxyvitamin D25-hydroxyvitamin DBiomarkersRetinoid X Receptor alphaVitamin DCross-sectionalMenTelomeresVitamin DVitamin D pathway SNPs

Identifiers

PMID26558766
PMCPMC4864153
OpenAlexW2287035361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.