Evidence map›Paper›PMID 26558609›Full record

ArticleBiomacromolecules2015

Antimicrobial Peptide Mimicking Primary Amine and Guanidine Containing Methacrylamide Copolymers Prepared by Raft Polymerization.

Sarah E Exley, Lea C Paslay, Gyan S Sahukhal, Brooks A Abel, Tyler D Brown, Charles L McCormick, Sabine Heinhorst, Veena Koul, Veena Choudhary, Mohamed O Elasri and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides.International journal of molecular sciences · 2020
    Review
  12. Article
  13. Review
  14. Antimicrobial Polymers: The Potential Replacement of Existing Antibiotics?International journal of molecular sciences · 2019
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sarah E ExleySchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Lea C PaslaySchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Gyan S SahukhalSchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Brooks A AbelSchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Tyler D BrownSchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Charles L McCormickSchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Sabine HeinhorstSchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Veena KoulSchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Veena ChoudharySchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Mohamed O ElasriSchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
Sarah E MorganSchool of Polymers and High Performance Materials, ‡Biological Sciences, and §Department of Chemistry and Biochemistry, The University of Southern Mississippi , Hattiesburg, Mississippi 39406, United States.
University of Southern Mississippi · USIndian Institute of Technology Delhi · IN

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI Vijay Rangachari · 2012 to 2026
$60.2M
NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Naturally occurring antimicrobial peptides (AMPs) display the ability to eliminate a wide variety of bacteria, without toxicity to the host eukaryotic cells. Synthetic polymers containing moieties mimicking lysine and arginine components found in AMPs have been reported to show effectiveness against specific bacteria, with the mechanism of activity purported to depend on the nature of the amino acid mimic. In an attempt to incorporate the antimicrobial activity of both amino acids into a single water-soluble copolymer, a series of copolymers containing lysine mimicking aminopropyl methacrylamide (APMA) and arginine mimicking guanadinopropyl methacrylamide (GPMA) were prepared via aqueous RAFT polymerization. Copolymers were prepared with varying ratios of the comonomers, with degree of polymerization of 35-40 and narrow molecular weight distribution to simulate naturally occurring AMPs. Antimicrobial activity was determined against Gram-negative and Gram-positive bacteria under conditions with varying salt concentration. Toxicity to mammalian cells was assessed by hemolysis of red blood cells and MTT assays of MCF-7 cells. Antimicrobial activity was observed for APMA homopolymer and copolymers with low concentrations of GPMA against all bacteria tested, with low toxicity toward mammalian cells.

Indexed as

AcrylamidesAminesAntimicrobial Cationic PeptidesArginineCell SurvivalErythrocytesGuanidinesHemolysisHumansLysineMCF-7 CellsMolecular StructurePeptidomimeticsPolymerizationPolymersAcrylamidesAminesAntimicrobial Cationic PeptidesArginineGuanidinesLysinemethacrylamidePeptidomimeticsPolymers

Identifiers

PMID26558609
PMCPMC4825813
OpenAlexW2339229246

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.