ReviewInternational journal of clinical practice2016
Predictive factors and clinical biomarkers for treatment in patients with chronic pain caused by osteoarthritis with a central sensitisation component.
Review in International journal of clinical practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effect of Initial Central Sensitization Severity on Treatment Response in Patients With Fibromyalgia
Investigation of the Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Patients With Fibromyalgia
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Extracorporeal Shock Wave Therapy for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Prescription Patterns of Benzodiazepines and Opioid Analgesics in Adults with and without Major Psychiatric Disorders: A Nationwide Cohort Study.Yonsei medical journal · 2026Article
- Neurophysiological, Radiological, and Molecular Biomarkers of Pain-Related Conditions: An Umbrella Review.Journal of clinical medicine · 2026Review
- Preoperative Central Sensitization Worsens Pain and Dissatisfaction Following Unicompartmental Knee Arthroplasty.Medicina (Kaunas, Lithuania) · 2025Article
- Intra-articular steroids for the treatment of coxarthrosis; a retrospective cohort study comparing three contrast techniques.Archives of orthopaedic and trauma surgery · 2024Article
- Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives.Pain and therapy · 2024Review
- Low central sensitisation inventory score is associated with better post-operative outcomes of osteotomy around the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Importance of nociplastic pain in patients with rheumatic diseases.Clinics (Sao Paulo, Brazil) · 2023Article
- Pain Management and Rehabilitation for Central Sensitization in Temporomandibular Disorders: A Comprehensive Review.International journal of molecular sciences · 2022Review
- Diagnosis of Central Sensitization and Its Effects on Postoperative Outcomes following Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Cultural Validation of the Chinese Central Sensitization Inventory in Patients with Chronic Pain and its Predictive Ability of Comorbid Central Sensitivity Syndromes.Journal of pain research · 2022Article
- Activity-related pain predicts pain and functional outcomes in people with knee osteoarthritis: A longitudinal study.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Cross-cultural adaptation and validation of the German Central Sensitization Inventory (CSI-GE).BMC musculoskeletal disorders · 2021Article
- Diagnostic accuracy of the clinical indicators to identify central sensitization pain in patients with musculoskeletal pain.Archives of physiotherapy · 2021Article
- Article
- Development of Postoperative Pain in Patients with End-Stage Knee Osteoarthritis Is Associated with Upregulation of Genes Related to Extracellular Matrix Degradation, Inflammation, and Apoptosis Measured in the Peripheral Blood before Knee Surgery.Life (Basel, Switzerland) · 2020Article
- Clinical Perspective on Pain and Pain Phenotypes in Osteoarthritis.Current rheumatology reports · 2018Review
- Traits associated with central pain augmentation in the Knee Pain In the Community (KPIC) cohort.Pain · 2018Article
- The clinical utility of gene expression examination in rheumatology.Mediterranean journal of rheumatology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 11 institutions in 11 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this non-systematic review was to provide a practical guide for clinicians on the evidence for central sensitisation in chronic osteoarthritis (OA) pain and how this pain mechanism can be addressed in terms of clinical diagnosis, investigation and treatment.
methodsThe authors undertook a non-systematic review of the literature including a MEDLINE search (search terms included central sensitisation, osteoarthritis, osteoarthrosis) for relevant and current clinical studies, systematic reviews and narrative reviews. Case reports, letters to the editor and similar literature sources were excluded. Information was organised to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations.
resultsThere is good evidence for a role of central sensitisation in chronic OA pain in a subgroup of patients. Clinically, a central sensitisation component in chronic OA pain can be suspected based on characteristic pain features and non-pain features seen in other conditions involving central sensitisation. However, there are currently no diagnostic inventories for central sensitisation specific to OA. Biomarkers may be helpful for confirming the presence of central sensitisation, especially when there is diagnostic uncertainty. Several non-pharmacological and pharmacological treatments may be effective in OA patients with central sensitisation features. Multimodal therapy may be required to achieve control of symptoms. DISCUSSION: Clinicians should be aware of central sensitisation in patients with chronic OA pain, especially in patients presenting with severe pain with unusual features.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.