ArticleEuropean thyroid journal2015
The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism.
Article in European thyroid journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 4 of them syntheses that pooled it.
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Who cites it
101 citing papers in PubMed, 4 syntheses or guidelines pooled it, 313 citations in OpenAlex.
- Impact of thyroid disorders on flow-mediated dilation: a systematic review and meta-analysis.Journal of endocrinological investigation · 2026Pooled it
- A systematic review of subclinical hyperthyroidism guidelines: a remarkable range of recommendations.European thyroid journal · 2024Pooled it
- Systematic review of thyroid function in NKX2-1-related disorders: Treatment and follow-up.PloS one · 2024Pooled it
- Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis.JAMA cardiology · 2019Pooled it
- Screening for atrial fibrillation according to serum thyroid-stimulating hormone: an opportunity for refinement?Annals of translational medicine · 2026Article
- Subclinical hyperthyroidism is associated with reduced spirometric parameters in asymptomatic adults: a cross-sectional observational study with etiology-stratified analysis.BMC pulmonary medicine · 2026Observational
- Malignancy Risk Within Hyperfunctioning Thyroid Nodules: Clinicopathologic Features and Diagnostic Implications.Diagnostics (Basel, Switzerland) · 2026Article
- Approach to the patient with severe hyperthyroidism-related complications.The Journal of clinical endocrinology and metabolism · 2026Review
- The public health burden of diabetes mellitus and thyroid disease: twin epidemics.Nature reviews. Endocrinology · 2026Review
- Drug-Induced Osteoporosis.Journal of clinical medicine · 2026Review
- Association between thyroid function and 10-year cardiovascular disease risk of patients with diabetes: a cross-sectional study using KNHANES 2013-2014.Journal of Yeungnam medical science · 2026Article
- Correlation of hypercalcemia with kidney stone formation and calcium-regulating hormone changes in patients with acute pancreatitis.World journal of gastrointestinal surgery · 2025Article
- Natural course of subclinical hyperthyroidism in primary care in the Netherlands.European thyroid journal · 2025Article
- EndoBridge 2024: pearls and highlights.Hormones (Athens, Greece) · 2025Article
- Application Value of Chemiluminescence Immunoassay in Thyroid Function Biochemical Testing.Journal of fluorescence · 2025Article
- Review
- Prolonged Normal Thyroid Function AfterJournal of clinical medicine · 2025Article
- Article
- The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study.Metabolites · 2025Article
- Systematic in-hospital screening and treatment for osteoporosis in a geriatric population with hip fractures.Journal of hospital medicine · 2025Article
41 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous subclinical hyperthyroidism (SHyper) is caused by Graves' disease, autonomously functioning thyroid nodules and multinodular goitre. Its diagnosis is based on a persistently subnormal serum thyroid-stimulating hormone (TSH) level with free thyroid hormone levels within their respective reference intervals. In 2014 the European Thyroid Association Executive Committee, given the controversies regarding the treatment of Endo SHyper, formed a task force to develop clinical practice guidelines based on the principles of evidence-based medicine. The task force recognized that recent meta-analyses, including those based on large prospective cohort studies, indicate that SHyper is associated with increased risk of coronary heart disease mortality, incident atrial fibrillation, heart failure, fractures and excess mortality in patients with serum TSH levels <0.1 mIU/l (grade 2 SHyper). Therefore, despite the absence of randomized prospective trials, there is evidence that treatment is indicated in patients older than 65 years with grade 2 SHyper to potentially avoid these serious cardiovascular events, fractures and the risk of progression to overt hyperthyroidism. Treatment could be considered in patients older than 65 years with TSH levels 0.1-0.39 mIU/l (grade 1 SHyper) because of their increased risk of atrial fibrillation, and might also be reasonable in younger (<65 years) symptomatic patients with grade 2 SHyper because of the risk of progression, especially in the presence of symptoms and/or underlying risk factors or co-morbidity. Finally, the task force concluded that there are no data to support treating SHyper in younger asymptomatic patients with grade 1 SHyper. These patients should be followed without treatment due to the low risk of progression to overt hyperthyroidism and the weaker evidence for adverse health outcomes.
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