Evidence map›Paper›PMID 26558220›Full record

ArticleInternational journal of ophthalmology2015

Orbital metastases in Italy.

Patrizio Magliozzi, Diego Strianese, Paola Bonavolontà, Mariantonia Ferrara, Pasquale Ruggiero, Raffaella Carandente, Giulio Bonavolontà, Fausto Tranfa

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In one paragraph

Article in International journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Patrizio MagliozziDepartment of Neuroscience, Odontostomatological and Reproductive Sciences, University of Naples Federico II, Naples 80131, Italy.
Diego StrianeseDepartment of Neuroscience, Odontostomatological and Reproductive Sciences, University of Naples Federico II, Naples 80131, Italy.
Paola BonavolontàDepartment of Neuroscience, Odontostomatological and Reproductive Sciences, University of Naples Federico II, Naples 80131, Italy.
Mariantonia FerraraDepartment of Neuroscience, Odontostomatological and Reproductive Sciences, University of Naples Federico II, Naples 80131, Italy.
Pasquale RuggieroDepartment of Neuroscience, Odontostomatological and Reproductive Sciences, University of Naples Federico II, Naples 80131, Italy.
Raffaella CarandenteDepartment of Neuroscience, Odontostomatological and Reproductive Sciences, University of Naples Federico II, Naples 80131, Italy.
Giulio BonavolontàDepartment of Neuroscience, Odontostomatological and Reproductive Sciences, University of Naples Federico II, Naples 80131, Italy.
Fausto TranfaDepartment of Neuroscience, Odontostomatological and Reproductive Sciences, University of Naples Federico II, Naples 80131, Italy.
Federico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo describe a series of Italian patients with orbital metastasis focusing on the outcomes in relation to the different primary site of malignancy.

methodsRetrospective chart review of 93 patients with orbital metastasis collected in a tertiary referral centre in a period of 38y and review of literature.

resultsOut of 93 patients, 52 were females and 41 were males. Median age at diagnosis was 51y (range 1 to 88y). The patients have been divided into four groups on the basis of the year of diagnosis. The frequency of recorded cases had decreased significantly (P<0.05) during the last 9.5y. Primary tumor site was breast in 36 cases (39%), kidney in 10 (11%), lung in 8 (9%), skin in 6 (6%); other sites were less frequent. In 16 case (17%) the primary tumor remained unknown. The most frequent clinical findings were proptosis (73%), limited ocular motility (55%), blepharoptosis (46%) and blurred vision (43%). The diagnosis were established by history, ocular and systemic evaluation, orbital imaging studies and open biopsy or fine needle aspiration biopsy (FNAB). Treatment included surgical excision, irradiation, chemotherapy, hormone therapy, or observation. Ninety-one percent of patients died of metastasis with an overall mean survival time (OMST) after the orbital diagnosis of 13.5mo.

conclusionBreast, kidney and lung are the most frequent primary sites of cancer leading to an orbital metastasis. When the primary site is unknown, gastrointestinal tract should be carefully investigated. In the last decade a decrease in the frequency of orbital metastasis has been observed. Surgery provides a local palliation. Prognosis remains poor with a OMST of 13.5mo ranging from the 3mo in the lung cancer to 24mo in the kidney tumor.

Indexed as

orbital metastasisprimary tumorsurvival time

Identifiers

PMID26558220
PMCPMC4630982
OpenAlexW2278764101

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.