ArticleInternational journal of ophthalmology2015
Diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging.
Article in International journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Resting-State fMRI Co-Activation Patterns Reveal Multiscale Brain Functional Alterations in Primary Angle-Closure Glaucoma: Transcriptomic, Cellular, Neurochemical, and Machine-Learning Signatures.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Abnormal topological properties and functional-structural coupling of large-scale brain networks in primary angle-closure glaucoma.Quantitative imaging in medicine and surgery · 2025Article
- Glaucoma, More than Meets the Eye: Patterns of Demyelination Revealed in Human Postmortem Glaucomatous Optic Nerve.Aging and disease · 2024Article
- Age-related changes in the healthy adult visual pathway: evidence from diffusion tensor imaging with fixel-based analysis.Radiologie (Heidelberg, Germany) · 2023Article
- Application of diffusion tensor imaging technology in glaucoma diagnosis.Frontiers in neuroscience · 2023Review
- Diffusion tensor imaging of horizontal extraocular muscles in patients with concomitant and paralytic esotropia.International journal of ophthalmology · 2023Article
- Magnetic resonance imaging assessment of the lateral geniculate nucleus volume and height in patients with glaucoma: a Meta-analysis.International journal of ophthalmology · 2023Article
- Visualization of human optic nerve by diffusion tensor mapping and degree of neuropathy.PloS one · 2022Article
- Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma?Frontiers in aging neuroscience · 2021Review
- Magnetic Resonance Spectroscopy Features of the Visual Pathways in Patients with Glaucoma.Clinical neuroradiology · 2019Article
- Normal tension glaucoma: from the brain to the eye or the inverse?Neural regeneration research · 2019Review
- Altered white matter structure in the visual system following early monocular enucleation.Human brain mapping · 2018Article
- Article
- MRI-derived diffusion parameters in the human optic nerve and its surrounding sheath during head-down tilt.NPJ microgravity · 2017Article
- Retinal Structures and Visual Cortex Activity are Impaired Prior to Clinical Vision Loss in Glaucoma.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the value of quantitative diffusion tensor imaging (DTI) in assessing the axonal and myelin damage of the optic nerves and optic radiations in patients with chronic primary angle-closure glaucoma (PACG) by using high-field magnetic resonance (MR) imaging (3T).
methodsTwenty patients with bilateral chronic PACG and twenty age- and sex matched disease-free control subjects were enrolled. Conventional MRI and DTI were performed on all subjects using 3T MR scanner. Mean diffusivity (MD), fractional anisotropy (FA), axial diffusivities (AD) and radial diffusivities (RD) of each optic nerve and each optic radiation were measured by using post-processing software of DTI studio 2.3, and then compared between left eyes and right eyes and between patients group and control group. The paired-sample t- test were used.
resultsThere was no abnormality in the shape and signal intensity of the optic nerves and optic radiations in patients group and control group on the conventional MRI. No significant differences were observed in the FA, MD, AD and RD between the right and left optic nerves and optic radiations within patients group and control group (P>0.05). The optic nerves and optic radiations of patients with chronic PACG, as compared with control subjects, had significantly higher MD, AD, RD and significantly lower FA (P<0.05).
conclusionThe diffusivity of optic nerves and optic radiations in chronic PACG group showed abnormal and diffusivity parameters could be used markers of axonal and myelin injury in glaucoma.
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