ReviewWorld journal of gastrointestinal pharmacology and therapeutics2015
Pharmacotherapy for the management of achalasia: Current status, challenges and future directions.
Review in World journal of gastrointestinal pharmacology and therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Updated Systematic Review of Achalasia, with a Focus on POEM Therapy.Digestive diseases and sciences · 2020Pooled it
- Efficacy and safety of a novel technique using endoscopic ultrasound-guided fine-needle injection of botulinum toxin and balloon dilation in achalasia.iGIE : innovation, investigation and insights · 2026Article
- Surgical management of achalasia.Abdominal radiology (New York) · 2025Review
- Evolving therapeutic approaches in achalasia: a comprehensive review of peroral endoscopic myotomy (POEM) vs. Heller's myotomy.Annals of medicine and surgery (2012) · 2025Review
- Achalasia in the Elderly: Diagnostic Approach and a Proposed Treatment Algorithm Based on a Comprehensive Literature Review.Journal of clinical medicine · 2021Review
- Endoscopic ultrasound: a powerful tool to modify treatment algorithms in opioid-induced achalasia.Surgical endoscopy · 2021Article
- Peroral endoscopic myotomy is a safe and effective treatment modality for geriatric patients with achalasia.Esophagus : official journal of the Japan Esophageal Society · 2020Article
- Esophagogastric Junction Outflow Obstruction: Current Approach to Diagnosis and Management.Current gastroenterology reports · 2020Review
- Bridging therapy for achalasia in a second trimester pregnant patient.Journal of family medicine and primary care · 2019Article
- An Overview of Achalasia and Its Subtypes.Gastroenterology & hepatology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article reviews currently available pharmacological options available for the treatment of achalasia, with a special focus on the role of botulinum toxin (BT) injection due to its superior therapeutic effect and side effect profile. The discussion on BT includes the role of different BT serotypes, better pharmacological formulations, improved BT injection techniques, the use of sprouting inhibitors, designer recombinant BT formulations and alternative substances used in endoscopic injections. The large body of ongoing research into achalasia and BT may provide a stronger role for BT injection as a form of minimally invasive, cost effective and efficacious form of therapy for patients with achalasia. The article also explores current issues and future research avenues that may prove beneficial in improving the efficacy of pharmacological treatment approaches in patients with achalasia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.