ArticleParkinson's disease2015
Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson's Disease.
Article in Parkinson's disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Automatic speech analysis combined with machine learning reliably predicts the motor state in people with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Effects of Deep-Brain Stimulation on Speech: Perceptual and Acoustic Data.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Effects of speech rate modifications on phonatory acoustic outcomes in Parkinson's disease.Frontiers in human neuroscience · 2024Article
- Prosody matters: Preserved prominence marking strategies in people with Parkinson's disease independent of motor status.PloS one · 2024Article
- Vowel production: a potential speech biomarker for early detection of dysarthria in Parkinson's disease.Frontiers in psychology · 2023Article
- Articulatory Gain Predicts Motor Cortex and Subthalamic Nucleus Activity During Speech.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Data mining of an acoustic biomarker in tongue cancers and its clinical validation.Cancer medicine · 2021Article
- Levodopa-Based Changes on Vocalic Speech Movements during Prosodic Prominence Marking.Brain sciences · 2021Article
- Vocalic transitions as markers of speech acoustic changes with STN-DBS in Parkinson's Disease.Journal of communication disorders · 2017Article
- Speech disorders in Parkinson's disease: early diagnostics and effects of medication and brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- The effect of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on the acoustic and prosodic features in patients with Parkinson's disease: A study protocol for the first trial on Iranian patients.Medical journal of the Islamic Republic of Iran · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose. To investigate the impact of deep brain stimulation of the subthalamic nucleus (STN DBS) and levodopa intake on vowel articulation in dysarthric speakers with Parkinson's disease (PD). Methods. Vowel articulation was assessed in seven Quebec French speakers diagnosed with idiopathic PD who underwent STN DBS. Assessments were conducted on- and off-medication, first prior to surgery and then 1 year later. All recordings were made on-stimulation. Vowel articulation was measured using acoustic vowel space and formant centralization ratio. Results. Compared to the period before surgery, vowel articulation was reduced after surgery when patients were off-medication, while it was better on-medication. The impact of levodopa intake on vowel articulation changed with STN DBS: before surgery, levodopa impaired articulation, while it no longer had a negative effect after surgery. Conclusions. These results indicate that while STN DBS could lead to a direct deterioration in articulation, it may indirectly improve it by reducing the levodopa dose required to manage motor symptoms. These findings suggest that, with respect to speech production, STN DBS and levodopa intake cannot be investigated separately because the two are intrinsically linked. Along with motor symptoms, speech production should be considered when optimizing therapeutic management of patients with PD.
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Registered trials
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