ArticleArab journal of urology2013
The use of small intestinal submucosa graft for hypospadias repair: Pilot study.
Article in Arab journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Anti-Fibrotic Properties of a Decellularized Extracellular Matrix Scaffold from Porcine Small Intestinal Submucosa in Normal Human and Keloid Fibroblasts.International journal of molecular sciences · 2025Article
- Two is Better than One: Evaluation of Single Versus Staged Approaches for Tubular Substitution Urethroplasty with Acellular Silk Fibroin Biomaterials in Rabbits.Tissue engineering and regenerative medicine · 2025Article
- Tissue Engineering for Penile Reconstruction.Bioengineering (Basel, Switzerland) · 2024Review
- Tissue Engineering Graft for Urethral Reconstruction: Is It Ready for Clinical Application?Urology research & practice · 2023Article
- Tailor-made natural and synthetic grafts for precise urethral reconstruction.Journal of nanobiotechnology · 2022Review
- Tissue Engineering and Regenerative Medicine in Pediatric Urology: Urethral and Urinary Bladder Reconstruction.International journal of molecular sciences · 2022Review
- Using of Single-Layer Porcine Small Intestinal Submucosa in Urethroplasty on a Beagle Model.BioMed research international · 2022Article
- Genitourinary Tissue Engineering: Reconstruction and Research Models.Bioengineering (Basel, Switzerland) · 2021Review
- Use of dCELL (Decellularized Human Dermis) in Repair of Urethrocutaneous Fistulas or Glans Dehiscence.Plastic and reconstructive surgery. Global open · 2020Article
- Placental membrane grafts for urethral replacement in a rabbit model: a pilot study.World journal of urology · 2020Article
- The current state of tissue engineering in the management of hypospadias.Nature reviews. Urology · 2020Review
- From Acellular Matrices to Smart Polymers: Degradable Scaffolds that are Transforming the Shape of Urethral Tissue Engineering.International journal of molecular sciences · 2019Review
- Current Status of Tissue Engineering in the Management of Severe Hypospadias.Frontiers in pediatrics · 2017Review
- Optimization of the current self-assembled urinary bladder model: Organ-specific stroma and smooth muscle inclusion.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the outcome of using commercially available (SIS) grafts for repairing hypospadias. Collagen-based acellular matrices, including SIS and bladder submucosa matrix, have been used to repair urethral strictures, with varying success, and patients with hypospadias and with inadequate or no genital skin need a substitute tissue for urethroplasty. PATIENTS AND
methodsThis pilot study included 12 patients (mean age 8 years, range 1.5-15) with hypospadias (distal in six, mid-shaft in four and proximal in two). They underwent a repair with four layers of prefabricated SIS as an onlay graft. The outcome was assessed for cosmetic appearance, urinary stream and the postvoid residual volume. The chi-squared and Mann-Whitney U-tests were used to assess the relationship between preoperative factors and the outcome of the repair with SIS grafting.
resultsThe mean (range) follow-up was 23 (6-36) months. Nine patients ultimately voided normally, with a good cosmetic appearance and no postvoid residual urine. Six patients had a successful repair with no further intervention, whilst three had small fistulae that were treated by simple closure. In three patients the graft failed, by complete disruption or stricture. Graft infection adversely affected the outcome of SIS grafting.
conclusionsThe prefabricated SIS graft can be used as an alternative substitute for urethral reconstruction when genital skin is insufficient or lacking, as in circumcised patients or a repeat hypospadias repair. Graft infection is the chief reason for graft failure and should be prevented. Further studies with more patients are needed to confirm these preliminary results.
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