Evidence map›Paper›PMID 26558098›Full record

ReviewArab journal of urology2013

Overactive bladder syndrome: Current pathophysiological concepts and therapeutic approaches.

Nadir I Osman, Christopher R Chapple

Abstract readReview
In one paragraph

Review in Arab journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. PATTERN OF OVERACTIVE BLADDER IN SOUTHEAST NIGERIA.Journal of the West African College of Surgeons
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nadir I OsmanDepartment of Urology, Royal Hallamshire Hospital, Sheffield, UK.
Christopher R ChappleDepartment of Urology, Royal Hallamshire Hospital, Sheffield, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe overactive bladder syndrome (OAB) is a highly prevalent and bothersome symptom complex. We review contemporary reports to provide an update of the key aspects of its pathogenesis and the therapeutic approaches.

methodsThe PUBMED database was searched for relevant publications in the period from 1 January 1985 to 1 May 2013, using the keywords 'overactive bladder', 'anti-muscarinics', 'β-3 agonists', 'intravesical botulinum toxin', 'tibial nerve stimulation and 'sacral neuromodulation'.

resultsIn all, 33 articles were selected for this review. OAB is very common, affecting 10-20% of the population. It is often bothersome and frequently affects the quality of life. The current definition of OAB remains a source of controversy. Anti-muscarinic agents remain the mainstay of pharmacotherapy. The new β-3 agonists have some efficacy whilst avoiding anti-cholinergic effects, and so might benefit patients who are unable to tolerate anti-muscarinic agents. Intravesical botulinum toxin is recommended for patients in whom oral pharmacotherapy fails, although the optimal parameters in terms of dosing, number of injections and injection site are yet to be fully established. Sacral neuromodulation is another option that has a good response in about half of patients.

conclusionsOAB remains an incompletely understood problem that presents a significant management challenge. A range of therapeutic options is now available for clinicians managing this problem.

Indexed as

AM, antimuscarinic agentAntimuscarinicsBotulinum toxinBTX, botulinum toxin ADO, detrusor overactivityER, extended-releaseMirabegronOAB, overactive bladder syndromeOveractive bladderPTNS, posterior tibial nerve stimulationSNM, sacral neuromodulation

Identifiers

PMID26558098
PMCPMC4443009

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.