ArticleIranian journal of basic medical sciences2015
Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice.
Article in Iranian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Polysaccharides fromCurrent medicinal chemistry · 2026Article
- Safranal Alleviates Cyclophosphamide Induced Testicular Toxicity in Rats.Food science & nutrition · 2025Article
- Preventive effects of quercetin against inflammation and apoptosis in cyclophosphamide-induced testicular damage.Iranian journal of basic medical sciences · 2024Article
- Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway.Frontiers in nutrition · 2023Review
- Identification of aldehyde oxidase 3 as a binding protein for squid ink polysaccharides using magnetic nanoparticles.RSC advances · 2021Article
- Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in aMarine drugs · 2020Article
- Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice.Oxidative medicine and cellular longevity · 2020Article
- Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43.Frontiers in pharmacology · 2019Article
- A Potential Adjuvant Agent of Chemotherapy: Sepia Ink Polysaccharides.Marine drugs · 2018Review
- The effect of melanin-free extract from Sepia esculenta ink on lipid peroxidation, protein oxidation and water-holding capacity of tilapia fillet during cold storage.Chemistry Central journal · 2018Article
- Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.Experimental and therapeutic medicine · 2017Article
- Squid ink polysaccharide prevents autophagy and oxidative stress affected by cyclophosphamide in Leydig cells of mice: a pilot study.Iranian journal of basic medical sciences · 2017Article
- Polysaccharide fromIranian journal of basic medical sciences · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. MATERIALS AND
methodsMale Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deacetylase 2 (HDAC2), quinone oxidoreductase 1 (NQO-1), and heme oxygenase 1 (HO-1) and phosphorylation level of protein kinase C (PKC) in testis were evaluated by Western blotting.
resultsData showed that SIP elevated expressions of NQO-1 and HO-1 genes, two downstream target molecules of Nrf2, via activating Nrf2 to play preventive roles on CP-treated testis, and further discovered that upstream regulators of Nrf2, keap-1, HDAC2, and PKC, were concerned with the regulation of Nrf2.
conclusionThese results suggest that SIP could effectively weaken CP-associated testicular damage via Nrf2/ARE signal pathway.
Indexed as
Identifiers
26557973PMC4633467W1640314835What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.