Evidence map›Paper›PMID 26557835›Full record

ReviewViszeralmedizin2015

Medical Therapy of Perianal Crohn's Disease.

Thomas Klag, Martin Goetz, Eduard F Stange, Jan Wehkamp

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viszeralmedizin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06051253 (Efficacy of Infliximab Treatment Based on TDM), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06051253 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

Efficacy of Infliximab Treatment Based on TDM (Therapeutic Drug Monitoring) in Adult Patients With Active Perianal Fistulizing Crohn's Disease

TypeinterventionalSponsorAsan Medical CenterRan2023 to 2027Enrolled86ConditionsCrohn Disease, Infliximab, Perianal Fistula Due to Crohn's Disease, Therapeutic Drug MonitoringArmsTDM-based infliximab intravenous therapy, Standard infliximab intravenous therapy
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Perianal Fistula; from Etiology to Treatment - A Review.Middle East journal of digestive diseases · 2024
    Review
  5. Review
  6. Review
  7. One-shot dalbavancin infusion combined with vacuum-assisted closure of Crohn's anal fistulas.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019
    Article
  8. Infertility in men with inflammatory bowel disease.World journal of gastrointestinal pharmacology and therapeutics · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Thomas KlagDepartment of Internal Medicine I, University of Tübingen, Tübingen, Germany.
Martin GoetzDepartment of Internal Medicine I, University of Tübingen, Tübingen, Germany.
Eduard F StangeDepartment of Internal Medicine I, Robert-Bosch-Hospital, Stuttgart, Germany.
Jan WehkampDepartment of Internal Medicine I, University of Tübingen, Tübingen, Germany.
University of Tübingen · DERobert Bosch Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDevelopment of perianal fistulas are a common feature of Crohn's disease (CD). Consequences are severe impairment of quality of life as well as potentially life-threatening complications like abscess formation or bacterial sepsis. Therefore, appropriate treatment is an important task in the management of CD.

methodsThis review describes the epidemiology, pathogenesis, diagnosis, and conservative medical treatment of perianal CD with regard to the available literature. In February 2015, a PubMed search was performed with the following terms (combined and separate): 'Crohn's disease management', 'Crohn's disease complications', 'perianal Crohn's disease', 'fistulizing Crohn's disease', 'perianal fistulas', 'fistula healing', 'fistula closure'. From the search results, 36 articles were chosen as core elements of this review.

resultsPelvic magnetic resonance imaging and rectal endosonography are established diagnostic approaches to evaluate perianal fistulas in conjunction with endoscopy. Antibiotics, thiopurines, and calcineurin inhibitors are useful agents in the management of perianal CD. The availability of anti-TNF-alpha therapies has substantially changed the prospects and goals of medical treatment, and fistula healing seems to be possible in a substantial proportion of patients.

conclusionAntibiotics and several immunosuppressive drugs have improved the treatment of fistulizing CD and should be combined with surgical measures.

Indexed as

Anti-TNF-alpha therapyCrohn's diseaseCrohn's disease complicationsInflammatory bowel diseasePerianal fistula

Identifiers

PMID26557835
PMCPMC4608613
OpenAlexW1587521437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.