ArticleImmune network2015
Altered Gut Microbiota Composition in Rag1-deficient Mice Contributes to Modulating Homeostasis of Hematopoietic Stem and Progenitor Cells.
Article in Immune network, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Molecular mechanisms in endometriosis: linking JAK/STAT pathway, ferroptosis, and microbial dysbiosis.Molecular biology reports · 2026Review
- Disrupted Tuzzerella abundance and impaired L-glutamine levels induce Treg accumulation in ovarian endometriosis: a comprehensive multi-omics analysis.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Major urinary protein (Microbiology spectrum · 2024Article
- The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment.Frontiers in immunology · 2024Review
- The Interaction between Gut Microbiota and Host Amino Acids Metabolism in Multiple Myeloma.Cancers · 2023Review
- Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Review
- Peptidoglycan-Mediated Bone Marrow Autonomic Neuropathy Impairs Hematopoietic Stem/Progenitor Cells via a NOD1-Dependent Pathway in db/db Mice.Stem cells international · 2022Article
- Attenuated asthma phenotype in mice with a fetal-like antigen receptor repertoire.Scientific reports · 2021Article
- Intricate Connections between the Microbiota and Endometriosis.International journal of molecular sciences · 2021Review
- Host Protective Mechanisms to Intestinal Amebiasis.Trends in parasitology · 2021Review
- Conventional Co-Housing Modulates Murine Gut Microbiota and Hematopoietic Gene Expression.International journal of molecular sciences · 2020Article
- Influence of gut microbiome on multiple myeloma: friend or foe?Journal for immunotherapy of cancer · 2020Article
- Attenuation of immune-mediated bone marrow damage in conventionally housed mice.Molecular carcinogenesis · 2020Article
- Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation.PloS one · 2019Article
- TRAF6 Distinctly Regulates Hematopoietic Stem and Progenitors at Different Periods of Development in Mice.Molecules and cells · 2018Article
- Brain-Gut-Bone Marrow Axis: Implications for Hypertension and Related Therapeutics.Circulation research · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoietic stem and progenitor cells (HSPCs) can produce all kind of blood lineage cells, and gut microbiota that consists of various species of microbe affects development and maturation of the host immune system including gut lymphoid cells and tissues. However, the effect of altered gut microbiota composition on homeostasis of HSPCs remains unclear. Here we show that compositional change of gut microbiota affects homeostasis of HSPCs using Rag1 (-/-) mice which represent lymphopenic condition. The number and proportions of HSPCs in Rag1 (-/-) mice are lower compared to those of wild types. However, the number and proportions of HSPCs in Rag1 (-/-) mice are restored as the level of wild types through alteration of gut microbiota diversity via transferring feces from wild types. Gut microbiota composition of Rag1 (-/-) mice treated with feces from wild types shows larger proportions of family Prevotellaceae and Helicobacterceae whereas lower proportions of family Lachnospiraceae compared to unmanipulated Rag1 (-/-) mice. In conclusion, gut microbiota composition of lymphopenic Rag1 (-/-) mice is different to that of wild type, which may lead to altered homeostasis of HSPCs.
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