ArticleBioMed research international2015
Burnout Is Associated with Reduced Parasympathetic Activity and Reduced HPA Axis Responsiveness, Predominantly in Males.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Biological Markers of Burnout Severity: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2026Pooled it
- Associations of sympathetic and parasympathetic activity in job stress and burnout: A systematic review.PloS one · 2018Pooled it
- Adrenal fatigue does not exist: a systematic review.BMC endocrine disorders · 2016Pooled it
- Trial
- Trial
- A Functionalistic Stress Recovery Intervention Improves Perceived Recovery Opportunities and Relaxational Behaviors: A Secondary Analysis of a Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Associations between burnout symptoms and social behaviour: exploring the role of acute stress and vagal function.BMC public health · 2022Trial
- Heart rate variability and burnout risk among healthy employees in jobs involving interaction with others.Frontiers in physiology · 2026Article
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Examining surgeon stress in robotic and laparoscopic surgery.Journal of robotic surgery · 2024Article
- Cortisol Reactivity to Acute Psychosocial Stress in Physician Burnout.Biomedicines · 2024Article
- Association between omega-3 index and depersonalization among healthcare workers in a university hospital: a cross-sectional study.Frontiers in psychiatry · 2024Article
- Coronary microvascular function in male physicians with burnout and job stress: an observational study.BMC medicine · 2023Observational
- Impact of autonomic regulation on burnout and performance in thoracic surgery residents.JTCVS open · 2022Article
- Determining the direction of prediction of the association between parasympathetic dysregulation and exhaustion symptoms.Scientific reports · 2022Article
- Article
- Article
- A Cognitive Behavioral Model Proposing That Clinical Burnout May Maintain Itself.International journal of environmental research and public health · 2021Review
- Smiling, Yawning, Jaw Functional Limitations and Oral Behaviors With Respect to General Health Status in Patients With Temporomandibular Disorder-Myofascial Pain With Referral.Frontiers in neurology · 2021Article
- Heart Rate Complexity in US Army Forward Surgical Teams During Pre Deployment Training.Military medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is mounting evidence that burnout is a risk factor for cardiovascular disease (CVD). Stress-related dysregulation of the sympathetic and parasympathetic system and the hypothalamic pituitary adrenal (HPA) axis may explain the enhanced risk for CVD. To test this hypothesis, 55 patients (34 males and 21 females) with burnout on sickness absence and 40 healthy participants (16 males and 24 females) were exposed to a psychosocial stressor consisting of mental arithmetic and public speech. Physiological variables (i.e., blood pressure, heart rate, cardiac output, vascular resistance, cortisol, and alpha-amylase) were measured. Basal levels, reactivity, and recovery were compared between groups. In male patients, baseline systolic blood pressure was higher, whereas basal alpha-amylase and cortisol reactivity were lower than in healthy males. In female patients, a tendency for lower basal cortisol was found as compared to healthy females. Furthermore, reduced basal heart rate variability and a trend for elevated basal cardiac output were observed in both male and female patients. Burnout is characterised by dysregulation of the sympathetic and parasympathetic system and the HPA axis, which was more pronounced in males than in females. This study further supports burnout as being a risk factor for CVD through dysregulation of the sympathetic and parasympathetic system and the HPA axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.