ArticleFrontiers in microbiology2015
Genome analysis of orf virus isolates from goats in the Fujian Province of southern China.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Isolation and whole-genome characterization of an Orf virus strain from a goat in Binzhou, Shandong Province, China.Archives of virology · 2026Article
- Unravelling the Evolutionary Complexity of Orf Virus: A Global and Multi-Host Perspective.Viruses · 2026Article
- Article
- The whole genome analysis of four Orf virus strains from Europe and South America.Virus evolution · 2026Article
- Infectivity of Parapoxvirus Orf after 35 Years of Refrigeration.Current microbiology · 2025Article
- Molecular perspective of Orf virus infection in Türkiye: a retrospective study between 2003 and 2021.Tropical animal health and production · 2025Article
- Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment.Virology journal · 2025Article
- Contagious ecthyma in small ruminants: from etiology to vaccine challenges - a review.Veterinary research communications · 2025Review
- The identification and genetic characteristics of the Orf virus strain (ORFV-CL24) isolated from Jilin province, China.Frontiers in microbiology · 2025Article
- A rare case of human infection with Orf virus in China, 2024.Frontiers in cellular and infection microbiology · 2025Article
- Genomic Differences and Mutations in Epidemic Orf Virus and Vaccine Strains: Implications for Improving Orf Virus Vaccines.Veterinary sciences · 2024Article
- The Global Evolutionary History of Orf Virus in Sheep and Goats Revealed by Whole Genomes Data.Viruses · 2024Article
- Retrospective research: identifying and conducting phylogenetic analyses on four Orf virus strains isolated in Yunnan province between 2021 and 2023-revealing their significance and characteristic features.Frontiers in veterinary science · 2024Article
- Molecular detection and phylogenetic analysis of Orf viruses from goats in Jiangxi province, China.Frontiers in veterinary science · 2024Article
- Dual analysis of wild-type and attenuatedmSphere · 2023Article
- The whole genomic analysis of the Orf virus strains ORFV-SC and ORFV-SC1 from the Sichuan province and their weak pathological response in rabbits.Functional & integrative genomics · 2023Article
- Complete genomic sequences and comparative analysis of two Orf virus isolates from Guizhou Province and Jilin Province, China.Virus genes · 2022Article
- Article
- Recombination drives the emergence of orf virus diversity: evidence from the first complete genome sequence of an Indian orf virus isolate and comparative genomic analysis.Archives of virology · 2022Article
- Genome-Wide Analysis and Molecular Characterization of Orf Virus Strain UPM/HSN-20 Isolated From Goat in Malaysia.Frontiers in microbiology · 2022Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orf virus (ORFV), a species of the genus Parapoxvirus of the family Poxviridae, causes non-systemic, highly contagious, and eruptive disease in sheep, goat, and other wild and domestic ruminants. Our previous work shows orf to be ubiquitous in the Fujian Province of China, a region where there is considerable heterogeneity among ORFVs. In this study, we sequenced full genomes of four Fujian goat ORFV strains (OV-GO, OV-YX, OV-NP, and OV-SJ1). The four strains were 132-139 kb in length, with each containing 124-132 genes and about 64% G+C content. The most notable differences between the four strains were found near the genome termini. OV-NP lacked seven and OV-SJ1 lacked three genes near the right terminus when compared against other ORFVs. We also investigated the skin-virulence of the four Fujian ORFVs in goats. The ORFVs with gene deletions showed low virulence while the ORFVs without gene deletions showed high virulence in goats suggesting gene deletion possibly leads to attenuation of ORFVs. Gene 134 was disrupted in OV-NP genome due to the lack of initial code. The phylogenetic tree based on complete Parapoxviruse genomes showed that sheep originated and goat originated ORFVs formed distinctly separate branches with 100% bootstrap. Based on the single gene phylogenetic tree of 132 genes of ORFVs, 47 genes can be easily distinguished as having originated from sheep or goats. In order to further reveal genetic variation presented in goat ORFVs and sheep ORFVs, we analyzed the deduced amino acid sequences of gene 008, multiple alignment of amino acid sequences of gene 008 from the genome of five goat ORFVs and four sheep ORFVs revealed 33 unique amino acids differentiating it as having sheep or goats as host. The availability of genomic sequences of four Fujian goat ORFVs aids in our understanding of the diversity of orf virus isolates in this region and can assist in distinguishing between orf strains that originate in sheep and goats.
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