Evidence map›Paper›PMID 26557092›Full record

ReviewFrontiers in physiology2015

Satellite cells in human skeletal muscle plasticity.

Tim Snijders, Joshua P Nederveen, Bryon R McKay, Sophie Joanisse, Lex B Verdijk, Luc J C van Loon, Gianni Parise

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04334343 (Investigating the Effects of Aerobic and Resistance Training in Vivo on Skeletal Muscle Metabolism in Vitro in Primary Human Muscle Cells), which is not on this map. Cited by 199 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 5 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04334343 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

Investigating the Effects of Aerobic and Resistance Training in Vivo on Skeletal Muscle Metabolism in Vitro in Primary Human Muscle Cells (MoTrMyo)

TypeinterventionalSponsorAdventHealth Translational Research InstituteRan2020 to 2026Enrolled179ConditionsPhysical ActivityArmsAdditional Muscle Biopsy Collection
3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 5 syntheses or guidelines pooled it, 347 citations in OpenAlex.

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139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Tim SnijdersDepartment of Kinesiology and Medical Physics and Applied Radiation Sciences, McMaster University Hamilton, ON, Canada ; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Maastricht, Netherlands.
Joshua P NederveenDepartment of Kinesiology and Medical Physics and Applied Radiation Sciences, McMaster University Hamilton, ON, Canada.
Bryon R McKayDepartment of Kinesiology and Medical Physics and Applied Radiation Sciences, McMaster University Hamilton, ON, Canada.
Sophie JoanisseDepartment of Kinesiology and Medical Physics and Applied Radiation Sciences, McMaster University Hamilton, ON, Canada.
Lex B VerdijkDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Maastricht, Netherlands.
Luc J C van LoonDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Maastricht, Netherlands.
Gianni PariseDepartment of Kinesiology and Medical Physics and Applied Radiation Sciences, McMaster University Hamilton, ON, Canada.
McMaster University · CAMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle satellite cells are considered to play a crucial role in muscle fiber maintenance, repair and remodeling. Our knowledge of the role of satellite cells in muscle fiber adaptation has traditionally relied on in vitro cell and in vivo animal models. Over the past decade, a genuine effort has been made to translate these results to humans under physiological conditions. Findings from in vivo human studies suggest that satellite cells play a key role in skeletal muscle fiber repair/remodeling in response to exercise. Mounting evidence indicates that aging has a profound impact on the regulation of satellite cells in human skeletal muscle. Yet, the precise role of satellite cells in the development of muscle fiber atrophy with age remains unresolved. This review seeks to integrate recent results from in vivo human studies on satellite cell function in muscle fiber repair/remodeling in the wider context of satellite cell biology whose literature is largely based on animal and cell models.

Indexed as

agingexerciseIGF-1interleukin-6muscle fiber hypertrophymuscle satellite cellsmyostatinPax7

Identifiers

PMID26557092
PMCPMC4617172
OpenAlexW1847176293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.