ArticleFrontiers in neural circuits2015
Quantification of mid and late evoked sinks in laminar current source density profiles of columns in the primary auditory cortex.
Article in Frontiers in neural circuits, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 36 citations in OpenAlex.
- Convolutional neural network models describe the encoding subspace of local circuits in auditory cortex.Nature neuroscience · 2026Article
- Neurons in auditory cortex integrate information within a constrained and context-invariant temporal window.Current biology : CB · 2025Article
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- Neurons in auditory cortex integrate information within constrained temporal windows that are invariant to the stimulus context and information rate.bioRxiv : the preprint server for biology · 2025Article
- Cortical layer-specific abnormalities in auditory responses in a mouse model of Fragile X Syndrome.Neurobiology of disease · 2025Article
- Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Reduced Neural Responses to Natural Foreground versus Background Sounds in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A sparse code for natural sound context in auditory cortex.Current research in neurobiology · 2024Article
- LFP polarity changes across cortical and eccentricity in primary visual cortex.Frontiers in neuroscience · 2023Article
- Visual cortical LFP in relation to the hippocampal theta rhythm in track running rats.Frontiers in cellular neuroscience · 2023Article
- Precise movement-based predictions in the mouse auditory cortex.Current biology : CB · 2022Article
- Article
- Laser-Induced Apoptosis of Corticothalamic Neurons in Layer VI of Auditory Cortex Impact on Cortical Frequency Processing.Frontiers in neural circuits · 2021Article
- What Triggers the Interictal Epileptic Spike? A Multimodal Multiscale Analysis of the Dynamic of Synaptic and Non-synaptic Neuronal and Vascular Compartments Using Electrical and Optical Measurements.Frontiers in neurology · 2021Article
- Task rule and choice are reflected by layer-specific processing in rodent auditory cortical microcircuits.Communications biology · 2020Article
- Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma.Frontiers in neuroscience · 2020Article
- Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex.Scientific reports · 2019Article
- Laminar Organization of FM Direction Selectivity in the Primary Auditory Cortex of the Free-Tailed Bat.Frontiers in neural circuits · 2019Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current source density (CSD) analysis assesses spatiotemporal synaptic activations at somatic and/or dendritic levels in the form of depolarizing current sinks. Whereas many studies have focused on the short (<50 ms) latency sinks, associated with thalamocortical projections, sinks with longer latencies have received less attention. Here, we analyzed laminar CSD patterns for the first 600 ms after stimulus onset in the primary auditory cortex of Mongolian gerbils. By applying an algorithm for contour calculation, three distinct mid and four late evoked sinks were identified in layers I, III, Va, VIa, and VIb. Our results further showed that the patterns of intracortical information-flow remained qualitatively similar for low and for high sound pressure level stimuli at the characteristic frequency (CF) as well as for stimuli ± 1 octave from CF. There were, however, differences associated with the strength, vertical extent, onset latency, and duration of the sinks for the four stimulation paradigms used. Stimuli one octave above the most sensitive frequency evoked a new, and quite reliable, sink in layer Va whereas low level stimulation led to the disappearance of the layer VIb sink. These data indicate the presence of input sources specifically activated in response to level and/or frequency parameters. Furthermore, spectral integration above vs. below the CF of neurons is asymmetric as illustrated by CSD profiles. These results are important because synaptic feedback associated with mid and late sinks-beginning at 50 ms post stimulus latency-is likely crucial for response modulation resulting from higher order processes like memory, learning or cognitive control.
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