Evidence map›Paper›PMID 26557041›Full record

ReviewCentral-European journal of immunology2015

Angiomodulatory properties of Rhodiola spp. and other natural antioxidants.

Dorota M Radomska-Leśniewska, Piotr Skopiński, Barbara J Bałan, Agata Białoszewska, Jarosław Jóźwiak, Dariusz Rokicki, Ewa Skopińska-Różewska, Anna Borecka, Agata Hevelke

Open access · goldAbstract readReview
In one paragraph

Review in Central-European journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Phenolic Compounds ofInternational journal of molecular sciences · 2023
    Review
  4. Review
  5. Article
  6. Review
  7. Novel therapies for diabetic retinopathy.Central-European journal of immunology · 2022
    Review
  8. Article
  9. Article
  10. Therapeutic potential of curcumin in eye diseases.Central-European journal of immunology · 2019
    Review
  11. Article
  12. Current pharmacology reports · 2017
    Article
  13. Different effects of feeding pregnant and lactating miceCentral-European journal of immunology · 2017
    Article
  14. Angiogenesis modulation by exogenous antioxidants.Central-European journal of immunology · 2017
    Review
  15. Article
  16. Immunomodulation on the ocular surface: a review.Central-European journal of immunology · 2016
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dorota M Radomska-LeśniewskaDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Piotr SkopińskiDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland ; Second Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.
Barbara J BałanDepartment of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, Poland.
Agata BiałoszewskaDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Jarosław JóźwiakDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Dariusz RokickiSecond Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.
Ewa Skopińska-RóżewskaDepartment of Pathology, Medical University of Warsaw, Warsaw, Poland ; Laboratory of Genetic Epidemiology and Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Anna BoreckaLaboratory of Genetic Epidemiology and Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Agata HevelkeDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw · PLWojskowy Instytut Higieny i Epidemiologii · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disturbances of angiogenesis and oxidative stress can lead to many serious diseases such as cancer, diabetes or ischemic heart disease. Substances neutralizing oxidative stress are known as antioxidants. They can affect angiogenesis process also, and thus, they modulate therapy results. Antioxidants become more and more frequently used in order to maintain homeostasis of the organism and diminish the risk of disease. Herein, we introduce some antioxidant preparations of natural plant origin (Rhodiola, Aloe vera, Resveratrol, Echinacea, Plumbagin) and antioxidant supplements (Padma 28, Reumaherb, Resvega). Analyses of their angiogenic properties, their multidirectional molecular effect on angiogenesis as well as medical application are within the scope of this review. Most of presented preparations down regulate neovascularization. They can be safely administered to patients with abnormally high angiogenesis. Rhodiola modulates, and Echinacea, Aloe vera and Plumbagin inhibit tumour-related angiogenesis in vitro and in vivo (animal models). Resveratrol and Resvega reduce neovascularization in the eye and may be applicable in eye disorders. Padma 28 preparation exhibits angioregulatory activity, decreasing high angiogenesis of cancer cells and increasing physiological angiogenesis, therefore can be used in therapy of patients with various disturbances of angiogenesis. Antioxidant application in the case of angiogenesis-related diseases should take into consideration angiogenic status of the patient.

Indexed as

angiomodulatory propertiesnatural antioxidants plant origin

Identifiers

PMID26557041
PMCPMC4637400
OpenAlexW2204720762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.