ReviewCentral-European journal of immunology2015
Current views on the mechanisms of immune responses to trauma and infection.
Review in Central-European journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 95 citations in OpenAlex.
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- Bacterial colonization of bone substitute materials used in oral surgery: mechanisms, clinical implications, and preventive strategies-A narrative review.Frontiers in microbiology · 2025Review
- Neutrophil-to-Albumin Ratio Predicts Stroke-Associated Pneumonia in Patients with Intracerebral Hemorrhage.Journal of inflammation research · 2025Article
- Three predictive scores compared in a retrospective multicenter study of nonunion tibial shaft fracture.World journal of orthopedics · 2024Article
- Review
- Correlation between Peripheric Blood Markers and Surgical Invasiveness during Humeral Shaft Fracture Osteosynthesis in Young and Middle-Aged Patients.Diagnostics (Basel, Switzerland) · 2024Article
- Uncovering the Unseen:International journal of molecular sciences · 2024Article
- Dysregulation of iron transport-related biomarkers in blood leukocytes is associated with poor prognosis of early trauma.Heliyon · 2024Article
- Is the prognosis of traumatic critically ill pediatric patients predictable? : A multicenter retrospective analysis.Wiener klinische Wochenschrift · 2023Article
- Elevation of neutrophil-derived factors in patients after multiple trauma.Journal of cellular and molecular medicine · 2023Article
- Efficacy comparison of antibiotic bone cement-coated implants and external fixations for treating infected bone defects.International orthopaedics · 2023Article
- Blood Count-Derived Inflammatory Markers Correlate with Lengthier Hospital Stay and Are Predictors of Pneumothorax Risk in Thoracic Trauma Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review.Anaesthesia · 2023Review
- Oncostatin M Receptor Type II Knockout Mitigates Inflammation and Improves Survival from Sepsis in Mice.Biomedicines · 2023Article
- Electrocardiographic Findings and Cardiac Troponin I Assay in Dogs with SIRS Diagnosis.Veterinary sciences · 2022Article
- Translational and Clinical Significance of DAMPs, PAMPs, and PRRs in Trauma-induced Inflammation.Archives of clinical and biomedical research · 2022Article
- Traumatized triad of complementopathy, endotheliopathy, and coagulopathy - Impact on clinical outcomes in severe polytrauma patients.Frontiers in immunology · 2022Article
- Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the World Health Organization, post-traumatic mortality rates are still very high and show an increasing tendency. Disorders of innate immune response that may increase the risk of serious complications play a key role in the immunological system response to trauma and infection. The mechanism of these disorders is multifactorial and is still poorly understood. The changing concepts of systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) early inflammatory response, presented in this work, have been extended to genetic studies. Overexpression of genes and increased production of immune response mediators are among the main causes of multiple organ dysfunction syndrome (MODS). Changes in gene expression detected early after injury precede the occurrence of subsequent complications with a typical clinical picture. Rapid depletion of energy resources leads to immunosuppression and persistent inflammation and immune suppression catabolism syndrome (PICS). Early diagnosis of immune disorders and appropriate nutritional therapy can significantly reduce the incidence of complications, length of hospital stay, and mortality. The study presents the development of knowledge and current views explaining the mechanisms of the immune response to trauma and infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.