SynthesisDisease markers2015
Prognostic Role of MicroRNA-200c-141 Cluster in Various Human Solid Malignant Neoplasms.
Synthesis in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Tumor characterization by ultrasound-release of multiple protein and microRNA biomarkers, preclinical and clinical evidence.PloS one · 2018Article
- The miR-200 family in ovarian cancer.Oncotarget · 2017Review
- Cross Talk between Cancer and Mesenchymal Stem Cells through Extracellular Vesicles Carrying Nucleic Acids.Frontiers in oncology · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The miR-200 family has emerged recently as a noticeable marker for predicting cancer prognosis and tumor progression. We aimed to review the evidence of miR-200c-141 genomic cluster as prognostic biomarkers in cancers. The results suggested that high level of miR-200c had no significant impact on OS (HR = 1.14 [0.77-1.69], P = 0.501) and DFS/PFS (HR = 0.72 [0.45-1.14], P = 0.161). Stratified analyses revealed that high miR-200c expression was significantly related to poor OS in serum/plasma (HR = 2.12 [1.62-2.77], P = 0.000) but not in tissues (HR = 0.89 [0.58-1.37], P = 0.599). High miR-200c expression was significantly associated with favorable DFS/PFS in tissues (HR = 0.56 [0.43-0.73], P = 0.000) but worse DFS/PFS in serum/plasma (HR = 1.90 [1.08-3.36], P = 0.027). For miR-141, we found that high miR-141 expression predicted no significant impact on OS (HR = 1.18 [0.74-1.88], P = 0.482) but poor DFS/PFS (HR = 1.11 [1.04-1.20], P = 0.003). Similarly, subgroup analyses showed that high miR-141 expression predicted poor OS in serum/plasma (HR = 4.34 [2.30-8.21], P = 0.000) but not in tissues (HR = 1.00 [0.92-1.09], P = 0.093). High miR-141 expression was significantly associated with worse DFS/PFS in tissues (HR = 1.12 [1.04-1.20], P = 0.002) but not in serum/plasma (HR = 0.90 [0.44-1.83], P = 0.771). Our findings indicated that, compared to their tissue counterparts, the expression level of miR-200c and miR-141 in peripheral blood may be more effective for monitoring cancer prognosis. High miR-141 expression was better at predicting tumor progression than survival for malignant tumors.
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