ArticleDisease markers2015
Complement Split Products in Amniotic Fluid in Pregnancies Subsequently Developing Early-Onset Preeclampsia.
Article in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- The Role of Complement and CD4 T Cells in Preeclampsia and Offspring Neurodevelopment.Current opinion in physiology · 2026Article
- The complement system in human pregnancy and preeclampsia.Frontiers in immunology · 2025Review
- The role of complement in normal pregnancy and preeclampsia.Frontiers in immunology · 2025Review
- The interval between the onset of increased blood pressure and proteinuria in preeclampsia and the contributing factors.Archives of gynecology and obstetrics · 2024Article
- Maternal serum proteomic profiles of pregnant women with type 1 diabetes.Scientific reports · 2022Article
- Molecular Advances in Preeclampsia and HELLP Syndrome.International journal of molecular sciences · 2022Review
- Complement inhibitor Crry expression in mouse placenta is essential for maintaining normal blood pressure and fetal growth.PloS one · 2020Article
- Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia.Frontiers in immunology · 2020Review
- Bioinformatics identification of potential genes and pathways in preeclampsia based on functional gene set enrichment analyses.Experimental and therapeutic medicine · 2019Article
- The role of the complement system in HIV infection and preeclampsia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or antiphospholipid antibodies.Annals of the rheumatic diseases · 2018Article
- The Immunogenetic Conundrum of Preeclampsia.Frontiers in immunology · 2018Review
- Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.Frontiers in medicine · 2017Article
- Adrenomedullin2 (ADM2)/Intermedin (IMD): A Potential Role in the Pathophysiology of Preeclampsia.The Journal of clinical endocrinology and metabolism · 2016Article
- Impaired Vasodilatory Responses of Omental Arteries to CGRP Family Peptides in Pregnancies Complicated by Fetal Growth Restriction.The Journal of clinical endocrinology and metabolism · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the second-trimester amniotic fluid concentrations of complement split products in pregnancies subsequently affected by early-onset preeclampsia. STUDY
designCohort of 731 women with singleton pregnancies undergoing second-trimester genetic amniocentesis followed up to delivery and analyzed as a nested case-control study. Cases of preeclampsia developing before 34 weeks' gestation (n = 15) were compared with 47 uncomplicated term controls. Amniotic fluid collected at amniocentesis was tested for complement split products Bb, C4a, C3a, and C5a.
resultsWomen who developed early-onset preeclampsia as compared with the term pregnant controls had significantly higher (P = 0.04) median amniotic fluid C3a levels (318.7 ng/mL versus 254.5 ng/mL). Median amniotic fluid Bb levels were also significantly higher (P = 0.03) in preeclamptic women than in normal pregnant women (1127 ng/mL versus 749 ng/mL). Median levels of C4a and C5a were not significantly different between the groups.
conclusionOur data suggest that complement activation in early pregnancy is associated with early-onset preeclampsia. We believe this to be the first prospective study to link complement activation in amniotic fluid in early pregnancy and later development of preeclampsia. Our findings provide evidence that immune dysregulation may precede the clinical manifestations of preeclampsia and that the alternative complement pathway is principally involved.
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