Evidence map›Paper›PMID 26556848›Full record

ArticleBritish journal of anaesthesia2015

Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults.

C Frerk, V S Mitchell, A F McNarry, C Mendonca, R Bhagrath, A Patel, E P O'Sullivan, N M Woodall, I Ahmad, Difficult Airway Society intubation guidelines working group

14 registry-linked trialsOpen access · bronzeAbstract readComment
In one paragraph

Article in British journal of anaesthesia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 14 registered trials, which are not on this map. Cited by 669 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
669citing papers in PubMed, 9 pooled it
178.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03118596 nacompletednot on this mapstarted 2017, after this paper: background citation

Fibre-optic Guided Tracheal Intubation Through Supraglottic Airway Devices - a Randomised Comparison Between I-gel and the LMA ProtectorTM

TypeinterventionalSponsorUniversity Hospitals Coventry and Warwickshire NHS TrustRan2017 to 2018Enrolled180ConditionsIntubation, Difficult or Failed, Laryngeal Masks, Airway ManagementArmsI-gel, LMA Protector
NCT03178318 nacompletednot on this mapstarted 2017, after this paper: background citation

An Observational Study Assessing the Position of Cricothyroid Membrane in Relation to Movement of Neck From Neutral to Extended Position

TypeinterventionalSponsorNorthampton General Hospital NHS TrustRan2017 to 2017Enrolled22ConditionsDifficult IntubationArmsultrasound
NCT03591432 naunknown statusnot on this mapstarted 2018, after this paper: background citation

A Randomised Controlled Trial Comparing Transnasal humidified Rapid insufflation Ventilatory Exchange (THRIVE) Pre-oxygenation and Apneic Oxygenation With Facemask Pre-oxygenation and Ventilation in Elderly Patients Undergoing Induction of Anaesthesia.

TypeinterventionalSponsorTao ZhangRan2018 to 2020Enrolled200ConditionsAnesthesia Intubation Complication, Postoperative ComplicationsArmsTransnasal humidified rapid insufflation ventilatory exchange (THRIVE), Facemask ventilation
NCT03613103 nacompletednot on this mapstarted 2018, after this paper: background citation

Airway Injuries After Intubation Using Videolaryngoscopy Highly Curved Blades Versus Direct Laryngoscopy for Adult Patients Requiring Tracheal Intubation: a Randomized Controlled Trial

TypeinterventionalSponsorUniversidad de AntioquiaRan2018 to 2023Enrolled716ConditionsAirway Trauma, Airway Complication of AnesthesiaArmsVideo laryngoscopy, Direct laryngoscopy
NCT04091568 completednot on this mapstarted 2019, after this paper: background citation

Comparison of Patients' Experience Following Awake and Asleep Fibreoptic Intubation

TypeobservationalSponsorUniversity Hospitals Coventry and Warwickshire NHS TrustRan2019 to 2020Enrolled130ConditionsTracheal Intubation, Intubation, Difficult
NCT04103047 completednot on this mapstarted 2019, after this paper: background citation

Temporomandibular Joint (TMJ) Dysfunction Following the Use of Supraglottic Airway Devices

TypeobservationalSponsorUniversity Hospitals Coventry and Warwickshire NHS TrustRan2019 to 2020Enrolled130ConditionsTemporomandibular Joint Disorder BilateralArmsSAD
NCT04124770 completednot on this mapstarted 2018, after this paper: background citation

Changes in Ultrasound-guided Skin Markings of the Cricothyroid Membrane in Three Different Neck Positions: a Prospective Observational Pilot Study

TypeobservationalSponsorUniversity of British ColumbiaRan2018 to 2019Enrolled58ConditionsCricothyroid Membrane, Ultrasound, Airway, CricothyroidotomyArmsMovement
NCT04352049 nacompletednot on this map

Comparing the Dynamics of Changes in Regional Cerebral Oxygen Saturation With Arterial Oxygen Partial Pressure With Two Techniques of Preoxygenation in Healthy Adults

TypeinterventionalSponsorComplexo Hospitalario Universitario de A CoruñaRan2012 to 2014Enrolled53ConditionsAnesthesia, FunctionalArmsPreoxygenation
NCT05666908 naunknown statusnot on this mapstarted 2023, after this paper: background citation

High-flow Nasal Oxygenation Improves Blood Oxygen Saturation During Asphyxia During Pulmonary Surgery With Double-lumen Endotracheal Intubation: a Randomized Controlled Study

TypeinterventionalSponsorShenzhen Second People's HospitalRan2023 to 2024Enrolled112ConditionsLung Neoplasms, PneumothoraxArmsHFNO
NCT05961254 unknown statusnot on this mapstarted 2023, after this paper: background citation

Role of Airwayultrasound in Predicting Difficult Endotracheal Intubation in Patients Undergoing General Anesthesia

TypeobservationalSponsorSohag UniversityRan2023 to 2024Enrolled170ConditionsPredict Diificult Endotracheal IntubationArmsassesment of difficult endotracheal intubation by airway ultrasound
NCT06121895 completednot on this mapstarted 2023, after this paper: background citation

Evaluation of Differences in Placement Success and Postoperative Complications Between Video Laryngeal Mask Airway and Fastrack Laryngeal Mask

TypeobservationalSponsorAnkara Etlik City HospitalRan2023 to 2024Enrolled101ConditionsThe Device Placement Times, Intubation Times, Postoperative ComplicationsArmsVideo Laryngeal Mask, Fastrack Laryngeal Mask
NCT06198504 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Impact of End-tidal Oxygen Monitoring During Preoxygenation Before Intubation for Acute Hypoxemic Respiratory Failure in ICU Setting: The PFOX Pilot Study.

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2024 to 2025Enrolled72ConditionsAcute Hypoxemic Respiratory FailureArmsProtocol using end-tidal oxygen monitoring during preoxygenation before intubation
NCT06578468 narecruitingnot on this mapstarted 2024, after this paper: background citation

Preoxygenation Using End-Tidal Oxygen for Rapid Sequence Intubation in the Emergency Department (The PREOXED Trial) - a Multicentre Stepped Wedge Cluster Randomised Control Trial

TypeinterventionalSponsorSydney Local Health DistrictRan2024 to 2025Enrolled1,400ConditionsCritical Illness, Hypoxia, Respiratory FailureArmsEnd-tidal oxygen monitor
NCT07759284 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Association Between Preoperative Oronasal Breathing Patterns and Endotracheal Tube Intolerance During Emergence From General Anesthesia: A Prospective Nested Case-Control Study

TypeobservationalSponsorPeking University People's HospitalRan2026 to 2026Enrolled224ConditionsCoughing Responses at Tracheal Extubation, Breathing Patterns
3 · Its place in the literature

Who cites it

669 citing papers in PubMed, 9 syntheses or guidelines pooled it, 2,120 citations in OpenAlex.

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  5. Short-term and long-term management of caustic-induced gastrointestinal injury: An evidence-based practice guidelines.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
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609 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

C FrerkDepartment of Anaesthesia, Northampton General Hospital, Billing Road, Northampton NN1 5BD, UK chris.frerk@ngh.nhs.uk.
V S MitchellDepartment of Anaesthesia and Perioperative Medicine, University College London Hospitals NHS Foundation Trust, 235 Euston Road, London NW1 2BU, UK.
A F McNarryDepartment of Anaesthesia, NHS Lothian, Crewe Road South, Edinburgh EH4 2XU, UK.
C MendoncaDepartment of Anaesthesia, University Hospitals Coventry & Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, UK.
R BhagrathDepartment of Anaesthesia, Barts Health, West Smithfield, London EC1A 7BE, UK.
A PatelDepartment of Anaesthesia, The Royal National Throat Nose and Ear Hospital, 330 Grays Inn Road, London WC1X 8DA, UK.
E P O'SullivanDepartment of Anaesthesia, St James's Hospital, PO Box 580, James's Street, Dublin 8, Ireland.
N M WoodallDepartment of Anaesthesia, The Norfolk and Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich NR4 7UY, UK.
I AhmadDepartment of Anaesthesia, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
Difficult Airway Society intubation guidelines working group
Barts Health NHS Trust · GBGuy's and St Thomas' NHS Foundation Trust · GBNHS Lothian · GBNorfolk and Norwich University Hospitals NHS Foundation Trust · GBNorthampton General Hospital · GBRoyal National Throat Nose and Ear Hospital · GBSt. James's Hospital · IEUniversity College London Hospitals NHS Foundation Trust · GBUniversity Hospitals Coventry and Warwickshire NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

These guidelines provide a strategy to manage unanticipated difficulty with tracheal intubation. They are founded on published evidence. Where evidence is lacking, they have been directed by feedback from members of the Difficult Airway Society and based on expert opinion. These guidelines have been informed by advances in the understanding of crisis management; they emphasize the recognition and declaration of difficulty during airway management. A simplified, single algorithm now covers unanticipated difficulties in both routine intubation and rapid sequence induction. Planning for failed intubation should form part of the pre-induction briefing, particularly for urgent surgery. Emphasis is placed on assessment, preparation, positioning, preoxygenation, maintenance of oxygenation, and minimizing trauma from airway interventions. It is recommended that the number of airway interventions are limited, and blind techniques using a bougie or through supraglottic airway devices have been superseded by video- or fibre-optically guided intubation. If tracheal intubation fails, supraglottic airway devices are recommended to provide a route for oxygenation while reviewing how to proceed. Second-generation devices have advantages and are recommended. When both tracheal intubation and supraglottic airway device insertion have failed, waking the patient is the default option. If at this stage, face-mask oxygenation is impossible in the presence of muscle relaxation, cricothyroidotomy should follow immediately. Scalpel cricothyroidotomy is recommended as the preferred rescue technique and should be practised by all anaesthetists. The plans outlined are designed to be simple and easy to follow. They should be regularly rehearsed and made familiar to the whole theatre team.

Indexed as

Practice Guidelines as TopicAirway ManagementHumansairway obstructioncomplicationsintubationintubation, endotrachealintubation, transtrachealventilation

Identifiers

PMID26556848
PMCPMC4650961
OpenAlexW2173578770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 8 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.