Evidence map›Paper›PMID 26556771›Full record

ArticleBrain research2016

Neuroglobin immunoreactivity in the human cochlea.

Nopawan Vorasubin, Seiji Hosokawa, Kumiko Hosokawa, Gail Ishiyama, Akira Ishiyama, Ivan A Lopez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Auditory function and dysfunction: estrogen makes a difference.Cellular and molecular life sciences : CMLS · 2020
    Review
  3. Impact of A90P, F106L and H64V mutations on neuroglobin stability and ligand binding kinetics.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019
    Article
  4. Neuroglobin Expression Models as a Tool to Study Its Function.Oxidative medicine and cellular longevity · 2019
    Review
  5. Article
  6. Immunohistochemical techniques for the human inner ear.Histochemistry and cell biology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Nopawan VorasubinDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1624, USA.
Seiji HosokawaDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1624, USA; Department of Otorhinolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Kumiko HosokawaDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1624, USA; Department of Otorhinolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Gail IshiyamaDepartment of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1624, USA.
Akira IshiyamaDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1624, USA.
Ivan A LopezDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1624, USA. Electronic address: ilopez@ucla.edu.
University of California, Los Angeles · USHamamatsu University School of Medicine · JP

Funding

The Otopathology of Hearing Loss: Genotype-Phenotype Correlation in Human TBU24DC011962 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISHIYAMA, AKIRA, LINTHICUM, FRED H · 2011 to 2015
$2.2M
NIDCD NIH HHS U24 DC011962NIDCD NIH HHS U24 DC011962-04
6 · The paper itself

Abstract

Neuroglobin (Ngb) is an oxygen-binding protein with a demonstrated role in endogenous neuroprotective mechanisms. It has been shown to function as a scavenger for reactive oxidizing species thereby assisting in cellular defense against oxidative stress. In the present study, we characterized the presence of Ngb in the human cochlea. Immunohistochemical staining was performed on formalin fixed celloidin human cochlea sections obtained from human temporal bones, using affinity purified polyclonal antibodies against Ngb. Thirty-six temporal bones were analyzed, 15 with normal otologic histories and 21 diagnosed with different inner ear pathologies. Ngb immunoreactivity (Ngb-IR) was consistently expressed in the neurons of spiral ganglia (SG) and supporting cells of the organ of Corti. There was a significant decrease of Ngb-IR in SGNs from specimens with inner ear pathologies when compared to normal specimens. In contrast, Ngb-IR in the organ of Corti did not show significant changes between pathological and normal specimens. The differential pattern of Ngb expression in these cochlear structures suggests that Ngb may participate in defense mechanisms in inner ear pathologies where oxidative stress is involved.

Indexed as

AdolescentAdultAgedAged, 80 and overChildCochleaFemaleGlobinsHumansImmunohistochemistryMaleMiddle AgedNerve Tissue ProteinsNeuroglobinSpecies SpecificityGlobinsNerve Tissue ProteinsNeuroglobinHuman temporal boneInner earNeuroglobinOxidative stressSpiral ganglia neuron

Identifiers

PMID26556771
PMCPMC4966546
OpenAlexW2106265264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.