ArticleClinical oral investigations2016
Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?
Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Apical Periodontitis May Exacerbate Ulcerative Colitis via Neutrophil Extracellular Trap-Mediated Systemic Inflammation and Intestinal Barrier Disruption in Mice.International endodontic journal · 2026Article
- Multiple Periapical Lesions Influence the Expression of TLR4/NF-κB Pathway Components and the Development of Hepatic Injuries in Healthy and Chronic Alcohol-Consuming Rats.International endodontic journal · 2026Article
- Pulpitis Transiently Affect Hepatic Bone Morphogenetic Protein 9 Expression by Lipopolysaccharide.International dental journal · 2026Article
- Apical periodontitis and its association with systemic biomarkers: bibliometric analysis of global scientific production and knowledge compilation map.Odontology · 2026Review
- Cellular and molecular immunomodulatory potential of red wine polyphenols in apical periodontitis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Association of tooth loss with circadian syndrome in US adults: the mediated role of systemic inflammation.Clinical oral investigations · 2025Article
- Association of participant reported oral health, tooth loss, interdental cleaning and dental visits with serum CRP.Scientific reports · 2025Article
- Association of periodontitis, tooth loss, and self-rated oral health with circadian syndrome in US adults: a cross-sectional population study.BMC oral health · 2025Article
- Therapeutic Potential of Local and Systemic Adipose-Derived Mesenchymal Stem Cell Injections in a Rat Model of Experimental Periodontitis: Implications for Cardiac Function.International journal of molecular sciences · 2025Article
- A Two-Way Communication Between Apical Periodontitis and Various Systemic Disorders: A Narrative Review.Cureus · 2025Review
- The Interaction of Apical Periodontitis, Cigarette Smoke, and Alcohol Consumption on Liver Antioxidant Status in Rats.International journal of molecular sciences · 2024Article
- Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoEInternational journal of oral science · 2024Article
- The association between dental caries and steroid-sensitive nephrotic syndrome in children.Pediatric nephrology (Berlin, Germany) · 2024Article
- Involvement of Root Canal Treatment in Pro-Inflammatory Processes - A Real-World Study.Pragmatic and observational research · 2024Article
- Article
- Five-year outcomes of immediate implant placement for mandibular molars with and without chronic apical periodontitis: A retrospective study.World journal of clinical cases · 2023Article
- Modulation of blood redox status by the progression of induced apical periodontitis in rats.Frontiers in physiology · 2023Article
- Association between Apical Periodontitis and Chronic Diseases: An Umbrella Review.Iranian endodontic journal · 2023Review
- Comparison of EASYDO ACTIVATOR, passive ultrasonic, and needle irrigation techniques on the treatment of apical periodontitis: a study in rats.Clinical oral investigations · 2022Article
- Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review.Medicina (Kaunas, Lithuania) · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to investigate whether apical periodontitis (AP) could cause systemic cytokine elevation and pathological changes in remote organs in an experimental animal model. MATERIALS AND
methodsAP was induced in 36 Sprague Dawley (SD) rats. Serum levels of C-reactive protein (CRP), interleukin 2 (IL-2), and interleukin 6 (IL-6) were measured by enzyme-linked immunosorbent assays at different time intervals (0, 6, 12, 24, 48, and 96 h and 1, 2, 3, 4, 5, and 6 weeks) after pulp exposure. Multiple organs (the aortic arch, myocardium, liver, and spleen) were collected for histological observation. The results were analyzed by one-way analysis of variance (ANOVA).
resultsSerum levels of CRP, IL-2, and IL-6 were significantly elevated at all time points assessed after 6, 24, and 96 h, respectively. The peak values of serum cytokines (CRP 6.363 ± 0.05 ng/ml, IL-2 21.997 ± 0.15 ng/L, and IL-6 2.406 ± 0.02 ng/L) were reached at 1, 4, and 2 weeks, respectively, followed by a decline. Time-dependent reversible histopathological changes were detected in the aortic arch, myocardium, and spleen, whereas irreversible changes were found in the liver.
conclusionsAP elevated the levels of CRP, IL-2, and IL-6 in rat blood serum, causing reversible changes in the aortic arch, myocardium, and spleen as well as irreversible changes in the liver. CLINICAL RELEVANCE: AP may trigger a systemic immune response, impair remote organs, and affect the general health of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.