ArticleInternational journal of molecular sciences2015
The Estrogen Receptor-β Expression in De Quervain's Disease.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Aucubin from Eucommiae Cortex Alleviates Tendinopathy via an Estrogen Receptor β-Mediated Mechanism.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Neuromusculoskeletal disorders in pregnancy revisited: Insights and clinical implications.Joint diseases and related surgery · 2025Review
- [Histopathological diagnostics for assessment questions of tendo-, ligamento-, and meniscus pathologies].Pathologie (Heidelberg, Germany) · 2025Review
- Halving of the meniscectomy rate and their costs in Italy: A 15-years period analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Annual Trends of High Tibial Osteotomy: Analysis of an Official Registry in Italy.Medicina (Kaunas, Lithuania) · 2024Article
- Article
- Approche de la douleur chronique au poignet chez les adultes: Revue des pathologies courantes à l'intention des praticiens des soins primaires.Canadian family physician Medecin de famille canadien · 2024Article
- Approach to chronic wrist pain in adults: Review of common pathologies for primary care practitioners.Canadian family physician Medecin de famille canadien · 2024Review
- Analysis of a National Database Investigating Development of Trigger Finger after Treatment of Dupuytren Disease.Plastic and reconstructive surgery. Global open · 2023Article
- Review
- Incidence and Risk Factors for Pregnancy-Related de Quervain's Tenosynovitis in South Korea: A Population-Based Epidemiologic Study.Clinics in orthopedic surgery · 2023Article
- Time to Reconsider Occupation Induced De Quervain's Tenosynovitis: An Updated Review of Risk Factors.Orthopedic reviews · 2022Article
- Association between de Quervain syndrome and herpes zoster: a population-based cohort study.BMJ open · 2021Article
- The role of estrogen and progesterone receptors in the rotator cuff disease: a retrospective cohort study.BMC musculoskeletal disorders · 2021Article
- Association of estrogen receptor β polymorphisms with posterior tibial tendon dysfunction.Molecular and cellular biochemistry · 2020Article
- Article
- ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study.Journal of orthopaedic surgery and research · 2018Article
- Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain's disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation of estrogen receptor (ER)-β expression to determine whether estrogen is involved in the pathogenesis of de Quervain's. Intraoperative retinaculum samples were collected from 16 patients with the ailment. Specimens were histologically graded by collagen structure and immunohistochemically evaluated by quantifying the expression of ER-β, interleukin (IL)-1β and IL-6 (inflammatory cytokines), cyclooxygenase (COX)-2 (an inflammatory enzyme), and vascular endothelial growth factor (VEGF), and Von Willebrand's factor (vWF). De Quervain's occurs primarily in women. The female:male ratio in our study was 7:1. We found that ER-β expression in the retinaculum was positively correlated with disease grade and patient age. Additionally, disease severity was associated with inflammatory factors--IL-1β and IL-6, COX-2, and VEGF and vWF in tenosynovial tissue. The greater the levels of ER-β expression, tissue inflammation, and angiogenesis are, the more severe de Quervain's disease is. ER-β might be a useful target for novel de Quervain's disease therapy.
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