Evidence map›Paper›PMID 26555936›Full record

ArticleThe Journal of clinical endocrinology and metabolism2016

Lipolytic Rate Associated With Intramyocardial Lipid in an HIV Cohort Without Increased Lipolysis.

Louisa C Howard, Chia-Ying Liu, Julia B Purdy, Peter Walter, David A Bluemke, Colleen Hadigan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Heart fat in HIV: marker or mediator of risk?Current opinion in HIV and AIDS · 2017
    Review
  4. Adipose Tissue in HIV Infection.Comprehensive Physiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Louisa C HowardLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (L.C.H., C.H.), Radiology and Imaging Sciences, Clinical Center (C.-Y.L., D.A.B.), Critical Care Medicine Department (J.B.P.), and National Institute of Diabetes and Digestive and Kidney Diseases (P.W.), National Institutes of Health, Bethesda Maryland 20892.
Chia-Ying LiuLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (L.C.H., C.H.), Radiology and Imaging Sciences, Clinical Center (C.-Y.L., D.A.B.), Critical Care Medicine Department (J.B.P.), and National Institute of Diabetes and Digestive and Kidney Diseases (P.W.), National Institutes of Health, Bethesda Maryland 20892.
Julia B PurdyLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (L.C.H., C.H.), Radiology and Imaging Sciences, Clinical Center (C.-Y.L., D.A.B.), Critical Care Medicine Department (J.B.P.), and National Institute of Diabetes and Digestive and Kidney Diseases (P.W.), National Institutes of Health, Bethesda Maryland 20892.
Peter WalterLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (L.C.H., C.H.), Radiology and Imaging Sciences, Clinical Center (C.-Y.L., D.A.B.), Critical Care Medicine Department (J.B.P.), and National Institute of Diabetes and Digestive and Kidney Diseases (P.W.), National Institutes of Health, Bethesda Maryland 20892.
David A BluemkeLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (L.C.H., C.H.), Radiology and Imaging Sciences, Clinical Center (C.-Y.L., D.A.B.), Critical Care Medicine Department (J.B.P.), and National Institute of Diabetes and Digestive and Kidney Diseases (P.W.), National Institutes of Health, Bethesda Maryland 20892.
Colleen HadiganLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (L.C.H., C.H.), Radiology and Imaging Sciences, Clinical Center (C.-Y.L., D.A.B.), Critical Care Medicine Department (J.B.P.), and National Institute of Diabetes and Digestive and Kidney Diseases (P.W.), National Institutes of Health, Bethesda Maryland 20892.
National Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Clinical Stable Isotope Research & SupportZICDK075039 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WALTER, PETER · 2009 to 2025
$23.2M
Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
Intramural NIH HHS
6 · The paper itself

Abstract

contextIndividuals with HIV have an elevated risk for developing cardiovascular disease compared to controls, particularly in relationship to abnormal deposition of lipid within various body compartments. Dysregulation of lipolysis may contribute to abnormal deposition of lipid in non-adipose tissues such as the heart, leading to untoward health consequences.

objectiveTo evaluate potential relationships between rates of whole-body lipolysis and intramyocardial lipid content in HIV-infected subjects compared to healthy controls.

designCross-sectional study.

settingNational Institutes of Health Clinical Research Center in Bethesda, Maryland.

participantsForty-six HIV-infected adults and 12 controls without known cardiovascular disease.

main outcome measureIntramyocardial lipid content quantified by MRI and rates of lipolysis determined using stable isotope tracer techniques.

resultsWe observed a significant positive correlation between the rate of appearance of glycerol and intramyocardial lipid overall (r = 0.323; P = .014) and among the HIV group separately (r = 0.361; P = .014). Multivariate regression analyses including HIV, lipid-lowering therapy, and diabetes identified both rate of appearance of glycerol and age as independent significant predictors of intramyocardial lipid (P = .01 and P = .03, respectively), but these were not significant with inclusion of visceral adipose in the analyses.

conclusionsTo our knowledge, this study is among the first in humans to characterize the relationship between lipid deposition in the myocardium and direct measurement of whole-body fatty acid metabolism. Our current findings contribute to the growing understanding of factors that promote myocardial steatosis, such as visceral adiposity, and implicate lipolysis as a potential target for interventions to optimize myocardial health.

Indexed as

Lipid MetabolismLipolysisAbdominal FatAdultAgingBody CompositionCohort StudiesCross-Sectional StudiesDiabetes MellitusFemaleGlycerolHIV InfectionsHumansHypolipidemic AgentsKineticsLiverGlycerolHypolipidemic Agents

Identifiers

PMID26555936
PMCPMC4701849
OpenAlexW2104050978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.