Evidence map›Paper›PMID 26555718›Full record

ReviewBiological psychology2016

Synaptic interactions and inhibitory regulation in auditory cortex.

Caitlin E Askew, Raju Metherate

Abstract readReview
In one paragraph

Review in Biological psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Context-Dependent Inhibitory Control of Stimulus-Specific Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Caitlin E AskewDepartment of Neurobiology and Behavior, Center for Hearing Research, University of California, Irvine, CA 92697, USA.
Raju MetherateDepartment of Neurobiology and Behavior, Center for Hearing Research, University of California, Irvine, CA 92697, USA. Electronic address: raju.metherate@uci.edu.

Funding

NIDCD T32 Interdisciplinary Training Program in Hearing ResearchT32DC010775 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Karina S Cramer, Raju Metherate · 2010 to 2026
$3.5M
UC Irvine Core Center for Hearing and Communication ResearchP30DC008369 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2007 to 2016
$3.3M
FUNCTIONS OF NICOTINE RECEPTORS IN SENSORY NEOCORTEXR01DA012929 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2000 to 2012
$2.4M
Functions of Nicotine Receptors in Sensory NeocortexR01DC013200 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2013 to 2017
$1.7M
Cellular Mechanisms of Aditory Cortex FunctionR01DC002967 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2003 to 2007
$913k
NIDA NIH HHS R01 DA012929NIDCD NIH HHS P30 DC008369NIDCD NIH HHS P30 DC08369NIDCD NIH HHS R01 DC002967NIDCD NIH HHS R01 DC013200NIDCD NIH HHS T32 DC010775PHS HHS NIDCD R01 DC013200
6 · The paper itself

Abstract

This Special Issue focuses on the auditory-evoked mismatch negativity (MMN), an electrophysiological index of change, and its reduction in schizophrenia. The following brief review is an attempt to complement the behavioral and clinical contributions to the Special Issue by providing basic information on synaptic interactions and processing in auditory cortex. A key observation in previous studies is that the MMN involves activation of cortical N-methyl-D-aspartate (NMDA) receptors. Yet, NMDA receptor activation is regulated by a number of synaptic events, which also may contribute to the MMN reduction in schizophrenia. Accordingly, this review will focus on synaptic interactions, notably inhibitory regulation of NMDA receptor-mediated activity, in auditory cortex.

Indexed as

AnimalsAuditory CortexElectrical SynapsesEvoked Potentials, AuditoryGABA AgentsHumansInterneuronsMiceRatsReceptors, GABA-BReceptors, GlutamateReceptors, N-Methyl-D-AspartateSchizophreniaGABA AgentsReceptors, GABA-BReceptors, GlutamateReceptors, N-Methyl-D-AspartateAuditory cortexGABAGlutamateMismatch negativityNeuromodulationNicotinic acetylcholine receptorNMDASynaptic integrationThalamocortical

Identifiers

PMID26555718
PMCPMC4808603

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.