Evidence map›Paper›PMID 26555668›Full record

ArticleBMC cancer2015

From palliative to curative treatment - stage IV mucinous adenocarcinoma, successfully treated with metronomic capecitabine in combination with Bevacizumab and surgery- a case report.

Karolina Vernmark, Maria Albertsson, Bergthor Björnsson, Thomas Gasslander, Per Sandström, Xiao-Feng Sun, Annika Holmqvist

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Karolina VernmarkDepartment of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. karolina.vernmark@regionostergotland.se.
Maria AlbertssonDepartment of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. maria.albertsson@regionostergotland.se.
Bergthor BjörnssonDepartment of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. bergthor.bjornsson@regionostergotland.se.
Thomas GasslanderDepartment of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. thomas.gasslander@regionostergotland.se.
Per SandströmDepartment of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. per.sandstrom@regionostergotland.se.
Xiao-Feng SunDepartment of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. xiao-feng.sun@liu.se.
Annika HolmqvistDepartment of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. annika.holmqvist@regionostergotland.se.
Linköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMucinous adenocarcinoma (MAC) represents 6-19 % of all colorectal carcinoma. It is associated with poorer response to chemotherapy and chemoradiotherapy. CASE PRESENTATION: A 27-year-old Swedish woman presented with stomach pain and weight loss, and was diagnosed with locally advanced MAC in the transverse colon as well as 3 liver metastases. Neoadjuvant treatment with fluorouracil, folinic acid and oxaliplatin (FLOX) failed due to several infections, pulmonary embolism and deteriorated performance status. The patient was therefore considered palliative. Palliative treatment with metronomic capecitabine 500 mg × 2 daily and bevacizumab every other week were initiated. After 4 months of treatment the tumors had regressed and the patient was able to undergo radical surgery, thereby changing the treatment intention from palliative to curative. No adjuvant chemotherapy was given. There were no signs of recurrence 9 months later.

conclusionsThe role of the combination of metronomic capecitabine and bevacizumab in patients with MAC merits further investigation.

Indexed as

Adenocarcinoma, MucinousAdultAntineoplastic Combined Chemotherapy ProtocolsBevacizumabCapecitabineFemaleFluorouracilHumansLeucovorinNeoplasm Recurrence, LocalPalliative CareBevacizumabCapecitabineFluorouracilLeucovorin

Identifiers

PMID26555668
PMCPMC4640161
OpenAlexW2103434973

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.