Evidence map›Paper›PMID 26555648›Full record

ArticleBMC genetics2015

Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains.

Qian Wang, Andrew T Grainger, Ani Manichaikul, Emily Farber, Suna Onengut-Gumuscu, Weibin Shi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Biomedicines · 2022
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  8. Genetic analysis of a mouse cross implicates an anti-inflammatory gene in control of atherosclerosis susceptibility.Mammalian genome : official journal of the International Mammalian Genome Society · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qian WangDepartment of Radiology & Medical Imaging, University of Virginia, Snyder Bldg Rm 266, 480 Ray C. Hunt Dr., P.O. Box 801339, Fontaine Research Park, Charlottesville, VA, 22908, USA. qw3q@Virginia.EDU.
Andrew T GraingerDepartment of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, USA. atg3qz@Virginia.EDU.
Ani ManichaikulCenter for Public Health and Genomics, University of Virginia, Charlottesville, VA, USA. am3xa@Virginia.EDU.
Emily FarberCenter for Public Health and Genomics, University of Virginia, Charlottesville, VA, USA. ef8j@Virginia.EDU.
Suna Onengut-GumuscuCenter for Public Health and Genomics, University of Virginia, Charlottesville, VA, USA. so4g@Virginia.EDU.
Weibin ShiDepartment of Radiology & Medical Imaging, University of Virginia, Snyder Bldg Rm 266, 480 Ray C. Hunt Dr., P.O. Box 801339, Fontaine Research Park, Charlottesville, VA, 22908, USA. ws4v@Virginia.EDU.
University of Virginia · US

Funding

Genetic link between type 2 diabetes and atherosclerosisR01DK097120 · NIDDK · UNIVERSITY OF VIRGINIA · PI SHI, WEIBIN · 2013 to 2016
$1.4M
H2 haplotype and atherosclerosisR21HL112281 · NHLBI · UNIVERSITY OF VIRGINIA · PI SHI, WEIBIN · 2012 to 2013
$414k
NHLBI NIH HHS HL112281NHLBI NIH HHS R21 HL112281NIDDK NIH HHS DK097120NIDDK NIH HHS R01 DK097120
6 · The paper itself

Abstract

backgroundIndividuals with dyslipidemia often develop type 2 diabetes, and diabetic patients often have dyslipidemia. It remains to be determined whether there are genetic connections between the 2 disorders.

methodsA female F2 cohort, generated from BALB/cJ (BALB) and SM/J (SM) Apoe-deficient (Apoe(-/-)) strains, was started on a Western diet at 6 weeks of age and maintained on the diet for 12 weeks. Fasting plasma glucose and lipid levels were measured before and after 12 weeks of Western diet. 144 genetic markers across the entire genome were used for quantitative trait locus (QTL) analysis.

resultsOne significant QTL on chromosome 9, named Bglu17 [26.4 cM, logarithm of odds ratio (LOD): 5.4], and 3 suggestive QTLs were identified for fasting glucose levels. The suggestive QTL near the proximal end of chromosome 9 (2.4 cM, LOD: 3.12) was replicated at both time points and named Bglu16. Bglu17 coincided with a significant QTL for HDL (high-density lipoprotein) and a suggestive QTL for non-HDL cholesterol levels. Plasma glucose levels were inversely correlated with HDL but positively correlated with non-HDL cholesterol levels in F2 mice on either chow or Western diet. A significant correlation between fasting glucose and triglyceride levels was also observed on the Western diet. Haplotype analysis revealed that "lipid genes" Sik3, Apoa1, and Apoc3 were probable candidates for Bglu17.

conclusionsWe have identified multiple QTLs for fasting glucose and lipid levels. The colocalization of QTLs for both phenotypes and the sharing of potential candidate genes demonstrate genetic connections between dyslipidemia and type 2 diabetes.

Indexed as

Crosses, GeneticGenetic LinkageAllelesAnimalsApolipoproteins EBlood GlucoseCholesterolChromosomes, MammalianDyslipidemiasFastingFemaleGenetic Association StudiesGenomeHyperglycemiaLod ScoreMaleApolipoproteins EBlood GlucoseCholesterolTriglycerides

Identifiers

PMID26555648
PMCPMC4641414
OpenAlexW2097527995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.