A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis.

Dibash K Das, Victoria Durojaiye, Adeodat Ilboudo, Michelle K Naidoo, Olorunseun Ogunwobi

Abstract readVideo-Audio Media

In one paragraph

Article in Journal of visualized experiments : JoVE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Mechanisms of hepatocellular carcinoma progression.World journal of gastroenterology · 2019
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dibash K DasDepartment of Biological Sciences, Hunter College of the City University of New York; Departments of Biology and Biochemistry, The Graduate Center of the City University of New York.

Victoria DurojaiyeDepartment of Biological Sciences, Hunter College of the City University of New York.

Adeodat IlboudoDepartment of Biological Sciences, Hunter College of the City University of New York.

Michelle K NaidooDepartment of Biological Sciences, Hunter College of the City University of New York.

Olorunseun OgunwobiDepartment of Biological Sciences, Hunter College of the City University of New York; Departments of Biology and Biochemistry, The Graduate Center of the City University of New York; Ogunwobi@genectr.hunter.cuny.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The majority of cancer-related deaths are caused by the metastasis of the cancer rather than the primary tumor itself. Yet, the underlying mechanisms of cancer metastasis are still unclear. Animal models are essential for elucidating the mechanisms and for evaluating novel strategies for the treatment of metastatic cancers. Here, an in-depth description of a "patient-like" orthotopic syngeneic mouse model for exploring the mechanisms of metastasis of solid organ tumors is provided. The survival surgical implantation of BNL 1ME A.7R.1 mouse hepatocellular carcinoma cells directly into the liver (the organ of origin) of the inbred wild-type immune competent laboratory mouse strain, BALB/c is described. The success and reproducibility of this methodology recommends it for widespread use in elucidating the biological mechanisms of solid organ cancer metastasis.

Indexed as

Disease Models, AnimalAnimalsLiver Neoplasms, ExperimentalMiceMice, Inbred BALB CNeoplasm MetastasisReproducibility of Results

Identifiers

PMID26555484

DOI10.3791/52858

PMCPMC4692691

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.