ArticleCurrent eye research2016
Defining the Relationships Among Retinal Function, Layer Thickness and Visual Behavior During Oxidative Stress-Induced Retinal Degeneration.
Article in Current eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Chronic exposure to aerosolized Arizona test dust reduces visual acuity in mice.Toxicology reports · 2026Article
- Interleukin 27-induced photoreceptor survival is associated with suppression of a novel Muller glia subpopulation.Cell communication and signaling : CCS · 2026Article
- Assessment of outer retinal thickness and function in mice after experimental optic nerve trauma.BMC ophthalmology · 2022Article
- The cytokine IL-27 reduces inflammation and protects photoreceptors in a mouse model of retinal degeneration.Journal of neuroinflammation · 2022Article
- Optimal Efficacy and Safety of Humanized Anti-Scg3 Antibody to Alleviate Oxygen-Induced Retinopathy.International journal of molecular sciences · 2021Article
- Distinct Nuclear Architecture of Photoreceptors and Light-Induced Behaviors in Different Strains of Mice.Translational vision science & technology · 2021Article
- Effect of Ubiquinol on Glaucomatous Neurodegeneration and Oxidative Stress: Studies for Retinal Ganglion Cell Survival and/or Visual Function.Antioxidants (Basel, Switzerland) · 2020Article
- Increased Neuroprotective Microglia and Photoreceptor Survival in the Retina from a Peptide Inhibitor of Myeloid Differentiation Factor 88 (MyD88).Journal of molecular neuroscience : MN · 2020Article
- Wnt signaling induces neurite outgrowth in mouse retinal ganglion cells.Experimental eye research · 2019Article
- Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse.Neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of this study was to identify how changes in retinal structure and function correlate with visual deficits during increasing amounts of retinal degeneration. MATERIALS AND
methodsRetinal degeneration was induced in adult mice by subretinal injections of paraquat (PQ) (0.2-1 mM). Retinal anatomy and photoreceptor layer thickness were quantified by histology and optical coherence tomography (OCT), retinal function was measured using electroretinography (ERG), and visual behavior were measured by optokinetic tracking, at 1 to 3 week post-injury.
resultsPhotoreceptor layer structure, function and visual behavior declined at a linear rate over time following PQ-induced degeneration, with the correlations between outcome measures being lowest at mild injury levels and increasing with injury severity. Overall reductions in visual acuity were highly correlated with declines in retinal thickness (r(2) = 0.78) and function (r(2) = 0.67) and retinal thickness correlated with photoreceptor function (r(2) = 0.72). ERG a-wave scotopic amplitudes showed a stronger correspondence to retinal structure and visual behavior than b-waves.
conclusionsMeasurements of photoreceptor loss at the structural and functional levels showed good correspondence with degeneration-associated changes in visual behavior after oxidative stress injury. The results provide new insight about the relative kinetics of measurements of retinal degeneration induced by oxidative stress, which could guide the choice of optimal outcome measurements for other retinal diseases.
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