Evidence map›Paper›PMID 26554915›Full record

ReviewCurrent opinion in virology2016

Autoimmunity in picornavirus infections.

Chandirasegaran Massilamany, Andreas Koenig, Jay Reddy, Sally Huber, Iwona Buskiewicz

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. [Adverse ocular effects of vaccinations].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2016
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chandirasegaran MassilamanySchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Andreas KoenigDepartment of Medicine and University of Vermont, Colchester, VT 05446, USA.
Jay ReddySchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Sally HuberDepartment of Pathology and Vermont Center for Immunobiology and Infectious Diseases, University of Vermont, Colchester, VT 05446, USA.
Iwona BuskiewiczDepartment of Pathology and Vermont Center for Immunobiology and Infectious Diseases, University of Vermont, Colchester, VT 05446, USA. Electronic address: Iwona.Buskiewicz@uvm.edu.
University of Vermont · USUniversity of Nebraska–Lincoln · US

Funding

VERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MATTHEWS, DWIGHT E · 2006 to 2011
$14.5M
Vermont Immunobioloigy/ Infectious Diseases CenterP20GM103496 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2012 to 2015
$8.7M
Tregulatory cells in myocarditisR01HL108371 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUBER, SALLY A · 2011 to 2014
$1.5M
Autoimmunity in the Mediation of Infectious MyocarditisR01HL114669 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI REDDY, JAY · 2013 to 2016
$1.4M
NCRR NIH HHS 5P20RR021905NCRR NIH HHS P20 RR021905NHLBI NIH HHS HL108371NHLBI NIH HHS HL114669NHLBI NIH HHS R01 HL108371NHLBI NIH HHS R01 HL114669NIGMS NIH HHS 8P20 GM103496NIGMS NIH HHS P20 GM103496
6 · The paper itself

Abstract

Enteroviruses are small, non-enveloped, positive-sense single-strand RNA viruses, and are ubiquitously found throughout the world. These viruses usually cause asymptomatic or mild febrile illnesses, but have a propensity to induce severe diseases including type 1 diabetes and pancreatitis, paralysis and neuroinflammatory disease, myocarditis, or hepatitis. This pathogenicity may result from induction of autoimmunity to organ-specific antigens. While enterovirus-triggered autoimmunity can arise from multiple mechanisms including antigenic mimicry and release of sequestered antigens, the recent demonstration of T cells expressing dual T cell receptors arising as a natural consequence of Theiler's virus infection is the first demonstration of this autoimmune mechanism.

Indexed as

AutoimmunityAnimalsAutoantigensCross ReactionsEpitopesHost-Pathogen InteractionsHumansMolecular MimicryPicornaviridaePicornaviridae InfectionsT-LymphocytesAutoantigensEpitopes

Identifiers

PMID26554915
PMCPMC4821705
OpenAlexW2180649545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.