ReviewDevelopmental biology2016
Hard to swallow: Developmental biological insights into pediatric dysphagia.
Review in Developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- The Frazier Water Protocol for Pediatric Dysphagia.The Laryngoscope · 2026Article
- Age-Related Dysphagia Among Children with 22q11.2-Deletion Syndrome.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Impact of Tracheostomy on Dysphagia in Children.Laryngoscope investigative otolaryngology · 2026Article
- Evaluation of the Efficacy of Focal Vibration Therapy-Novafon as an Assistive Therapeutic Tool for Children With Feeding and Swallowing Disorders.Journal of oral rehabilitation · 2025Article
- Development of eating skills in infants and toddlers from a neuropediatric perspective.Italian journal of pediatrics · 2024Review
- Localization of TRPV3/4 and PIEZO1/2 sensory receptors in murine and human larynges.Laryngoscope investigative otolaryngology · 2022Article
- Pediatric dysphagia overview: best practice recommendation study by multidisciplinary experts.World journal of pediatrics : WJP · 2022Review
- Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.Disease models & mechanisms · 2022Article
- Article
- Advances in Swallowing Neurophysiology across Pediatric Development: Current Evidence and Insights.Current physical medicine and rehabilitation reports · 2021Article
- Mother-to-Child Transmission of Arboviruses during Breastfeeding: From Epidemiology to Cellular Mechanisms.Viruses · 2021Review
- Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.International journal of pediatric otorhinolaryngology · 2021Article
- Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.Human molecular genetics · 2020Article
- Variations in maternal vitamin A intake modifies phenotypes in a mouse model of 22q11.2 deletion syndrome.Birth defects research · 2020Article
- Suckling, Feeding, and Swallowing: Behaviors, Circuits, and Targets for Neurodevelopmental Pathology.Annual review of neuroscience · 2020Review
- Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome.Human molecular genetics · 2020Article
- Persistent Feeding and Swallowing Deficits in a Mouse Model of 22q11.2 Deletion Syndrome.Frontiers in neurology · 2020Article
- Why Does the Face Predict the Brain? Neural Crest Induction, Craniofacial Morphogenesis, and Neural Circuit Development.Frontiers in physiology · 2020Review
- Abnormal Nutritive Sucking as an Indicator of Neonatal Brain Injury.Frontiers in pediatrics · 2020Review
- Nutritive sucking abnormalities and brain microstructural abnormalities in infants with established brain injury: a pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2019Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Pediatric dysphagia-feeding and swallowing difficulties that begin at birth, last throughout childhood, and continue into maturity--is one of the most common, least understood complications in children with developmental disorders. We argue that a major cause of pediatric dysphagia is altered hindbrain patterning during pre-natal development. Such changes can compromise craniofacial structures including oropharyngeal muscles and skeletal elements as well as motor and sensory circuits necessary for normal feeding and swallowing. Animal models of developmental disorders that include pediatric dysphagia in their phenotypic spectrum can provide mechanistic insight into pathogenesis of feeding and swallowing difficulties. A fairly common human genetic developmental disorder, DiGeorge/22q11.2 Deletion Syndrome (22q11DS) includes a substantial incidence of pediatric dysphagia in its phenotypic spectrum. Infant mice carrying a parallel deletion to 22q11DS patients have feeding and swallowing difficulties that approximate those seen in pediatric dysphagia. Altered hindbrain patterning, craniofacial malformations, and changes in cranial nerve growth prefigure these difficulties. Thus, in addition to craniofacial and pharyngeal anomalies that arise independently of altered neural development, pediatric dysphagia may result from disrupted hindbrain patterning and its impact on peripheral and central neural circuit development critical for feeding and swallowing. The mechanisms that disrupt hindbrain patterning and circuitry may provide a foundation to develop novel therapeutic approaches for improved clinical management of pediatric dysphagia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.