ArticleACS nano2016
Fast Stiffness Mapping of Cells Using High-Bandwidth Atomic Force Microscopy.
Article in ACS nano, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Article
- Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration.Small science · 2025Review
- The effects of mechanical stimulation on the morphology and function of spinal ligament cells.BMC musculoskeletal disorders · 2025Article
- Activity-dependent glassy cell mechanics Ⅰ: Mechanical properties measured with active microrheology.Biophysical journal · 2023Article
- Acousto-holographic reconstruction of whole-cell stiffness maps.Nature communications · 2022Article
- Sensing red blood cell nano-mechanics: Toward a novel blood biomarker for Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Spatial mapping of the collagen distribution in human and mouse tissues by force volume atomic force microscopy.Scientific reports · 2020Article
- Cellular nanoscale stiffness patterns governed by intracellular forces.Nature materials · 2019Article
- Visco-Node-Pore Sensing: A Microfluidic Rheology Platform to Characterize Viscoelastic Properties of Epithelial Cells.iScience · 2019Article
- Noninvasive monitoring of single-cell mechanics by acoustic scattering.Nature methods · 2019Article
- Determination of the Elastic Moduli of a Single Cell Cultured on a Rigid Support by Force Microscopy.Biophysical journal · 2018Article
- A High-Q AFM Sensor Using a Balanced Trolling Quartz Tuning Fork in the Liquid.Sensors (Basel, Switzerland) · 2018Article
- Characterizing cellular mechanical phenotypes with mechano-node-pore sensing.Microsystems & nanoengineering · 2018Article
- Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy.International journal of nanomedicine · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The cytoskeleton controls cellular morphology and mediates the mechanical interactions between a cell and its environment. Atomic force microscopy (AFM) has the unique capability to map cytoskeletal mechanics and structures with nanometer resolution. However, whole-cell cytomechanical imaging with conventional AFM techniques is limited by low imaging speed. Here, we present fast nanomechanical mapping of cells using high-bandwidth AFM (HB-AFM), where >10(6) nanoindentation measurements were acquired in ∼10 min-a task that would take weeks to finish using conventional AFM. High-bandwidth measurements enabled capture of the entire tip-sample interaction for each tap on cells, engendering a new measurement ("force phase") that exceeds the contrast of conventional tapping mode and enabling spectral visualization of >10 harmonics. The abundance of measurements allowed discovery of subtle cytomechanical features, including the stiffness of fibers of the cellular spectrin network in situ. This approach bridges HB-AFM and high-harmonic imaging and opens future opportunities for measuring the dynamic mechanical properties of living cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.