Evidence map›Paper›PMID 26554401›Full record

ReviewGenomics2016

The sequence of sequencers: The history of sequencing DNA.

James M Heather, Benjamin Chain

Abstract readHistorical ArticleReview
In one paragraph

Review in Genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 386 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
386citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

386 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. High-Resolution Chloroplast SNV Profiling of 409 Grapevine (International journal of molecular sciences · 2026
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326 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James M HeatherDivision of Infection & Immunity, UCL Cruciform Building, Gower Street, London, United Kingdom. Electronic address: James.Heather.10@ucl.ac.uk.
Benjamin ChainDivision of Infection & Immunity, UCL Cruciform Building, Gower Street, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Determining the order of nucleic acid residues in biological samples is an integral component of a wide variety of research applications. Over the last fifty years large numbers of researchers have applied themselves to the production of techniques and technologies to facilitate this feat, sequencing DNA and RNA molecules. This time-scale has witnessed tremendous changes, moving from sequencing short oligonucleotides to millions of bases, from struggling towards the deduction of the coding sequence of a single gene to rapid and widely available whole genome sequencing. This article traverses those years, iterating through the different generations of sequencing technology, highlighting some of the key discoveries, researchers, and sequences along the way.

Indexed as

High-Throughput Nucleotide SequencingHistory, 20th CenturyHistory, 21st CenturyNanotechnologySequence Analysis, DNADNAHistoryRNASequencerSequencing

Identifiers

PMID26554401
PMCPMC4727787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.