ArticleRNA (New York, N.Y.)2016
Long-range RNA pairings contribute to mutually exclusive splicing.
Article in RNA (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Long-range mRNA folding shapes expression and sequence of bacterial genes.Molecular cell · 2026Article
- Regulatory paradigm of Dscam1 stochastic alternative splicing through conserved long-range RNA structures.Nucleic acids research · 2026Article
- Long-range mRNA folding shapes expression and sequence of bacterial genes.bioRxiv : the preprint server for biology · 2025Article
- Article
- Trans-splicing facilitated by RNA pairing greatly expands sDscam isoform diversity but not homophilic binding specificity.Science advances · 2022Article
- Recent advances in RNA structurome.Science China. Life sciences · 2022Review
- Hidden RNA pairings counteract the "first-come, first-served" splicing principle to drive stochastic choice inScience advances · 2022Article
- Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene.Nucleic acids research · 2021Article
- Complex RNA Secondary Structures Mediate Mutually Exclusive Splicing of ColeopteraFrontiers in genetics · 2021Article
- May the Odds Be Ever in Your Favor: Non-deterministic Mechanisms Diversifying Cell Surface Molecule Expression.Frontiers in cell and developmental biology · 2021Review
- Two Isoforms ofFrontiers in cell and developmental biology · 2021Article
- RNA secondary structures inRNA (New York, N.Y.) · 2020Article
- Alternate RNA Structures.Cold Spring Harbor perspectives in biology · 2020Review
- Revisiting Dscam diversity: lessons from clustered protocadherins.Cellular and molecular life sciences : CMLS · 2019Review
- Competing RNA pairings in complex alternative splicing of a 3' variable region.RNA (New York, N.Y.) · 2018Article
- Article
- Review
- The determinants of alternative RNA splicing in human cells.Molecular genetics and genomics : MGG · 2017Review
- Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing.RNA biology · 2017Article
- Computational approaches for the discovery of splicing regulatory RNA structures.Biochimica et biophysica acta. Gene regulatory mechanismsReview
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutually exclusive splicing is an important means of increasing the protein repertoire, by which the Down's syndrome cell adhesion molecule (Dscam) gene potentially generates 38,016 different isoforms in Drosophila melanogaster. However, the regulatory mechanisms remain obscure due to the complexity of the Dscam exon cluster. Here, we reveal a molecular model for the regulation of the mutually exclusive splicing of the serpent pre-mRNA based on competition between upstream and downstream RNA pairings. Such dual RNA pairings confer fine tuning of the inclusion of alternative exons. Moreover, we demonstrate that the splicing outcome of alternative exons is mediated in relative pairing strength-correlated mode. Combined comparative genomics analysis and experimental evidence revealed similar bidirectional structural architectures in exon clusters 4 and 9 of the Dscam gene. Our findings provide a novel mechanistic framework for the regulation of mutually exclusive splicing and may offer potentially applicable insights into long-range RNA-RNA interactions in gene regulatory networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.