ArticleProceedings of the National Academy of Sciences of the United States of America2015
A vacuolar phosphate transporter essential for phosphate homeostasis in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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95 citing papers in PubMed, 244 citations in OpenAlex.
- The PHO1 protein family in phosphate export and beyond.Plant physiology · 2026Review
- Temporal Phosphorus Allocation and Resorption Plasticity Drive Interspecific Phosphorus-Use Efficiency in Rice-Rapeseed Rotations.Plant, cell & environment · 2026Article
- Structural and dynamic insights into SPDT for phosphorus allocation in rice.Science China. Life sciences · 2026Article
- Arbuscular Mycorrhizal Fungi Modulate Variety-Specific Phosphate Transporter Gene Expression in Aerobic Rice Under Phosphorus-Limited Soil Conditions.Plants (Basel, Switzerland) · 2026Article
- The SPX protein family in plants: from phosphate sensors to multifunctional signaling hubs.Stress biology · 2026Review
- Multi-Omics Reveals Domestication-Associated Shifts in Phosphorus Adaptation Strategies in Tomato.Plants (Basel, Switzerland) · 2026Article
- Molecular mechanism of phosphate import by the bacterial PstSCAB transporter.Nature communications · 2026Article
- Comparative analysis of seven types of phosphate transporters in forty species from the phylogenetic and transcriptomic perspective.PloS one · 2026Article
- Characterization of theGenes · 2025Article
- A Multidrug and Toxic Compound Extrusion Transporter, RgMATE6, Facilitates Vacuolar Transport of Acteoside inPlants (Basel, Switzerland) · 2025Article
- Molecular mechanism underlying phosphate distribution by SULTR family transporter SPDT inScience advances · 2025Article
- ZxNHX1 from a xerophyte outperforms AtNHX1 in sequestering NaPlant biotechnology journal · 2025Article
- Widespread Presence of SPX and Its Potential Role as a Phosphorus Nutrient Regulator in Dinoflagellates.Microorganisms · 2025Article
- Haplotype characterization of phosphorus homeostasis gene,3 Biotech · 2025Article
- NNature communications · 2025Article
- Natural variation in the GmVPE1 promoter contributes to phosphorus re-translocation to seeds and improves soybean yield.Plant biotechnology journal · 2025Article
- Structural mechanism underlying PHO1;H1-mediated phosphate transport in Arabidopsis.Nature plants · 2025Article
- Mobilization and recycling of intracellular phosphorus in response to availability.Quantitative plant biology · 2025Review
- From genes to traits: maximizing phosphorus utilization efficiency in crop plants.Frontiers in plant science · 2025Review
- Crossed wires: diatom phosphate sensing mechanisms coordinate nitrogen metabolism.Plant signaling & behavior · 2024Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inorganic phosphate (Pi) is stored in the vacuole, allowing plants to adapt to variable Pi availability in the soil. The transporters that mediate Pi sequestration into vacuole remain unknown, however. Here we report the functional characterization of Vacuolar Phosphate Transporter 1 (VPT1), an SPX domain protein that transports Pi into the vacuole in Arabidopsis. The vpt1 mutant plants were stunted and consistently retained less Pi than wild type plants, especially when grown in medium containing high levels of Pi. In seedlings, VPT1 was expressed primarily in younger tissues under normal conditions, but was strongly induced by high-Pi conditions in older tissues, suggesting that VPT1 functions in Pi storage in young tissues and in detoxification of high Pi in older tissues. As a result, disruption of VPT1 rendered plants hypersensitive to both low-Pi and high-Pi conditions, reducing the adaptability of plants to changing Pi availability. Patch-clamp analysis of isolated vacuoles showed that the Pi influx current was severely reduced in vpt1 compared with wild type plants. When ectopically expressed in Nicotiana benthamiana mesophyll cells, VPT1 mediates vacuolar influx of anions, including Pi, SO4(2-), NO3(-), Cl(-), and malate with Pi as that preferred anion. The VPT1-mediated Pi current amplitude was dependent on cytosolic phosphate concentration. Single-channel analysis showed that the open probability of VPT1 was increased with the increase in transtonoplast potential. We conclude that VPT1 is a transporter responsible for vacuolar Pi storage and is essential for Pi adaptation in Arabidopsis.
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