ArticleScientific reports2015
Fibrosis is a common outcome following total knee arthroplasty.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- No difference between mobile and fixed bearing in primary total knee arthroplasty: a meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- A practical toolbox for modelling fibrosis in vitro.Nature biomedical engineering · 2026Review
- Manipulation under anaesthesia and/or lysis of adhesions prior to revision total knee arthroplasty increases the risk of subsequent revision.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Review
- Biocompatibility and healing patterns in experimentally induced canine tibial fractures using Pedicle screw-Rod external fixation.Animal models and experimental medicine · 2026Article
- Article
- A novel infrapatellar fat pad preservation technique in anterior cruciate ligament reconstruction reduces postoperative pain and cartilage damage: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Article
- Limited evidence for the usage of renin-angiotensin-aldosterone pathway blockers to prevent arthrofibrosis after total knee arthroplasty. A systematic review of clinical evidence.Journal of experimental orthopaedics · 2024Review
- Ultrasound Elastography Assessment of Knee Intra-Articular Adhesions at Varying Knee Angles.Bioengineering (Basel, Switzerland) · 2024Article
- Removal of the infrapatellar fat pad and associated synovium benefits female guinea pigs in the Dunkin Hartley model of idiopathic osteoarthritis.Annals of translational medicine · 2024Article
- AdipoRon reduces TGFβ1-mediated collagen deposition in vitro and alleviates knee stiffness in vivo.Journal of cellular physiology · 2024Article
- Single-cell and bulk tissue sequencing unravels the heterogeneity of synovial microenvironment in arthrofibrosis.iScience · 2023Article
- Minoxidil weakens newly synthesized collagen in fibrotic synoviocytes from osteoarthritis patients.Journal of experimental orthopaedics · 2023Article
- Manipulation under Anesthesia Following TKA with Persona IQ: A Case Series.Journal of orthopaedic case reports · 2023Article
- The effect of losartan on range of motion and rates of manipulation in total knee arthroplasty: a retrospective matched cohort study.Archives of orthopaedic and trauma surgery · 2023Article
- The role of leukotriene inhibition using a 5-lipoxygenase (5-LO) inhibitor in a joint contracture model.Journal of experimental orthopaedics · 2023Article
- MAVRIC based T2 mapping assessment of infrapatellar fat pad scarring in patients with total knee arthroplasty.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Revision total knee arthroplasty for arthrofibrosis improves range of motion.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation.Arthritis research & therapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total knee arthroplasty (TKA) is one of the most successful orthopaedic procedures that alleviates pain and restores function in patients with degenerative knee joint diseases. Arthrofibrosis, abnormal scarring in which dense fibrous tissue prevents normal range of motion, develops in ~3-10% of TKA patients. No prophylactic intervention is available and treatment is restricted to aggressive physiotherapy or revision surgery. Tissue was collected from patients undergoing primary (n = 30) or revision (n = 27) TKA. Revision patients were stratified as non-arthrofibrotic and arthrofibrotic. Tissue was macroscopically and histologically compared to improve our understanding of the pathophysiology of arthrofibrosis. Macroscopically, tissue from primary TKA presents as homogenous, fatty tissue whereas tissue from revision TKA presents as dense, pigmented tissue. Histologically, there was dramatic tissue remodelling, increased collagen deposition and increased (myo)fibroblast staining in tissue from revision TKA. Significantly, tissue architecture was similar between revision patients regardless of clinically diagnosis. There are significant differences in architecture and composition of tissue from revision TKA over primary TKA. Surprisingly, whether revision TKA were clinically diagnosed as arthrofibrotic or non-arthrofibrotic there were still significant differences in fibrotic markers compared to primary TKA suggesting an ongoing fibrotic process in all revision knees.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.